In the absence of an intact interferon (IFN) response, mammals may be susceptible to lethal
viral infection. IFNs are secreted cytokines that activate a signal transduction cascade …

Healthcare, as a basic human right, has often become the focus of the development of
innovative technologies. Technological progress has significantly contributed to the …

The human genetic code encrypted in thousands of genes holds the secret for synthesis of
proteins that drive all biological processes necessary for normal life and death. Though the …

COVID‐19 is a pandemic disease caused by the new coronavirus SARS‐CoV‐2 that mostly
affects the respiratory system. The consequent inflammation is not able to clear viruses. The …

Interferon (IFN) signaling induces the expression of a wide array of genes, collectively
referred to as IFN-stimulated genes (ISGs) that generally function to inhibit viral replication …

The infection of mammalian cells by viruses and innate immune responses to infection are
spatiotemporally organized processes. Cytosolic RNA sensors trigger nuclear translocation …

Interferons are a group of immunomodulatory substances produced by the human immune
system in response to the presence of pathogens, especially during viral and bacterial …

Patients with epidermodysplasia verruciformis (EV) and biallelic null mutations of TMC6
(encoding EVER1) or TMC8 (EVER2) are selectively prone to disseminated skin lesions due …

Cellular intrinsic immunity, mediated by the expression of an array of interferon-stimulated
antiviral genes, is a vital part of host defense. We have previously used a bioinformatic …

The time and cost of developing new drugs have led many groups to limit their search for
therapeutics to compounds that have previously been approved for human use. Many …