Hypoxia-induced carbonic anhydrase IX as a target for cancer therapy: from biology to clinical use
J Pastorek, S Pastorekova - Seminars in cancer biology, 2015 - Elsevier
The tumor microenvironment includes a complicated network of physiological gradients
contributing to plasticity of tumor cells and heterogeneity of tumor tissue. Hypoxia is a key …
contributing to plasticity of tumor cells and heterogeneity of tumor tissue. Hypoxia is a key …
The role of hypoxia-inducible factors in tumorigenesis
EB Rankin, AJ Giaccia - Cell Death & Differentiation, 2008 - nature.com
Hypoxia-inducible factors (HIFs) are essential mediators of the cellular oxygen-signaling
pathway. They are heterodimeric transcription factors consisting of an oxygen-sensitive …
pathway. They are heterodimeric transcription factors consisting of an oxygen-sensitive …
Combined antiangiogenic and anti–PD-L1 therapy stimulates tumor immunity through HEV formation
Inhibitors of VEGF (vascular endothelial growth factor)/VEGFR2 (vascular endothelial growth
factor receptor 2) are commonly used in the clinic, but their beneficial effects are only …
factor receptor 2) are commonly used in the clinic, but their beneficial effects are only …
Direct regulation of TWIST by HIF-1α promotes metastasis
Stabilization of the hypoxia-inducible factor-1α (HIF-1α) transcription complex, caused by
intratumoural hypoxia, promotes tumour progression and metastasis, leading to treatment …
intratumoural hypoxia, promotes tumour progression and metastasis, leading to treatment …
Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy
JL Tatum - International journal of radiation biology, 2006 - Taylor & Francis
Purpose: The Cancer Imaging Program of the National Cancer Institute convened a
workshop to assess the current status of hypoxia imaging, to assess what is known about the …
workshop to assess the current status of hypoxia imaging, to assess what is known about the …
Molecular targeting of hypoxia in radiotherapy
Hypoxia (low O 2) is an essential microenvironmental driver of phenotypic diversity in
human solid cancers. Hypoxic cancer cells hijack evolutionarily conserved, O 2-sensitive …
human solid cancers. Hypoxic cancer cells hijack evolutionarily conserved, O 2-sensitive …
Pathophysiological basis for the formation of the tumor microenvironment
MR Horsman, P Vaupel - Frontiers in oncology, 2016 - frontiersin.org
Poor microenvironmental conditions are a characteristic feature of solid tumors. Such
conditions occur because the tumor vascular supply, which develops from the normal host …
conditions occur because the tumor vascular supply, which develops from the normal host …
Relation of a hypoxia metagene derived from head and neck cancer to prognosis of multiple cancers
Affymetrix U133plus2 GeneChips were used to profile 59 head and neck squamous cell
cancers. A hypoxia metagene was obtained by analysis of genes whose in vivo expression …
cancers. A hypoxia metagene was obtained by analysis of genes whose in vivo expression …
Berry fruits for cancer prevention: current status and future prospects
NP Seeram - Journal of Agricultural and Food Chemistry, 2008 - ACS Publications
Overwhelming evidence suggests that edible small and soft-fleshed berry fruits may have
beneficial effects against several types of human cancers. The anticancer potential of berries …
beneficial effects against several types of human cancers. The anticancer potential of berries …