Focal adhesion kinase (FAK) is a key regulator of growth factor receptor-and integrin-
mediated signals, governing fundamental processes in normal and cancer cells through its …

Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that plays critical roles in
integrin-mediated signal transductions and also participates in signaling by other cell …

Mechanical forces associated with blood flow play important roles in the acute control of
vascular tone, the regulation of arterial structure and remodeling, and the localization of …

▪ Abstract Src family protein tyrosine kinases are activated following engagement of many
different classes of cellular receptors and participate in signaling pathways that control a …

Endothelial cell migration is essential to angiogenesis. This motile process is directionally
regulated by chemotactic, haptotactic, and mechanotactic stimuli and further involves …

The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

Activated rhoA, a ras-related GTP-binding protein, stimulates the appearance of stress
fibers, focal adhesions, and tyrosine phosphorylation in quiescent cells (Ridley, AJ, and A …

▪ Abstract Focal adhesions are sites of tight adhesion to the underlying extracellular matrix
developed by cells in culture. They provide a structural link between the actin cytoskeleton …

A single intravascular injection of a cyclic peptide or monoclonal antibody antagonist of
integrin ccVps disrupts ongoing angiogenesis on the chick chorioallantoic membrane …

Blood vessels are constantly exposed to hemodynamic forces in the form of cyclic stretch
and shear stress due to the pulsatile nature of blood pressure and flow. Endothelial cells …