Osteosarcoma (OS) is the most common primary malignancy of the bone and has a high
propensity for local invasion and metastasis. Although combining surgery with …

Osteosarcoma is the most common primary bone cancer in children and young adults.
Limited progress has been made in improving the survival outcomes in patients with …

Osteosarcomas are the most frequent primary bone sarcomas, affecting mainly children,
adolescents, and young adults, and with a second peak of incidence in elderly individuals …

Ewing sarcoma, a highly aggressive bone and soft-tissue cancer, is considered a prime
example of the paradigms of a translocation-positive sarcoma: a genetically rather simple …

The immune system evolved to distinguish non-self from self to protect the organism. As
cancer is derived from our own cells, immune responses to dysregulated cell growth present …

Chimeric antigen receptor (CAR) T cell (CAR-T cell) therapy based on gene editing
technology represents a significant breakthrough in personalized immunotherapy for human …

The WNT pathway is one of the major signaling cascades frequently deregulated in human
cancer. While research had initially focused on signal transduction centered on β-catenin as …

The potential for immunotherapy as a treatment option for cancer is clear from remarkable
responses of some leukemia patients to adoptive cell transfer using autologous T cells …

Osteosarcoma is the most common bone tumor in children and young adults, with few
advances in survival and treatment, especially for metastatic disease, in the last 30 years …

Sarcomas are uncommon malignancies of mesenchymal origin that can arise throughout the
human lifespan, at any part of the body. Surgery remains the optimal treatment modality …