Virulence factors in coagulase-negative staphylococci

A França, V Gaio, N Lopes, LDR Melo - Pathogens, 2021 - mdpi.com
Coagulase-negative staphylococci (CoNS) have emerged as major pathogens in healthcare-
associated facilities, being S. epidermidis, S. haemolyticus and, more recently, S …

Biofilms in endodontics—current status and future directions

P Neelakantan, M Romero, J Vera, U Daood… - International journal of …, 2017 - mdpi.com
Microbiota are found in highly organized and complex entities, known as biofilms, the
characteristics of which are fundamentally different from microbes in planktonic …

Reassessing the role of type II toxin-antitoxin systems in formation of Escherichia coli type II persister cells

F Goormaghtigh, N Fraikin, M Putrinš, T Hallaert… - MBio, 2018 - Am Soc Microbiol
Persistence is a reversible and low-frequency phenomenon allowing a subpopulation of a
clonal bacterial population to survive antibiotic treatments. Upon removal of the antibiotic …

Enhanced antibiotic resistance development from fluoroquinolone persisters after a single exposure to antibiotic

TC Barrett, WWK Mok, AM Murawski… - Nature …, 2019 - nature.com
Bacterial persisters are able to tolerate high levels of antibiotics and give rise to new
populations. Persister tolerance is generally attributed to minimally active cellular processes …

Prophages and growth dynamics confound experimental results with antibiotic-tolerant persister cells

A Harms, C Fino, MA Sørensen, S Semsey, K Gerdes - MBio, 2017 - Am Soc Microbiol
Bacterial persisters are phenotypic variants that survive antibiotic treatment in a dormant
state and can be formed by multiple pathways. We recently proposed that the second …

Single-cell imaging and characterization of Escherichia coli persister cells to ofloxacin in exponential cultures

F Goormaghtigh, L Van Melderen - Science advances, 2019 - science.org
Bacterial persistence refers to the capacity of small subpopulations within clonal populations
to tolerate antibiotics. Persisters are thought to originate from dormant cells in which …

Quorum quenching of Streptococcus mutans via the nano-quercetin-based antimicrobial photodynamic therapy as a potential target for cariogenic biofilm

M Pourhajibagher, M Alaeddini, S Etemad-Moghadam… - BMC microbiology, 2022 - Springer
Background Quorum sensing (QS) system can regulate the expression of virulence factors
and biofilm formation in Streptococcus mutans. Antimicrobial photodynamic therapy (aPDT) …

Mutations in respiratory complex I promote antibiotic persistence through alterations in intracellular acidity and protein synthesis

B Van den Bergh, H Schramke, JE Michiels… - Nature …, 2022 - nature.com
Antibiotic persistence describes the presence of phenotypic variants within an isogenic
bacterial population that are transiently tolerant to antibiotic treatment. Perturbations of …

The human oral virome: shedding light on the dark matter

A Martínez, R Kuraji, YL Kapila - Periodontology 2000, 2021 - Wiley Online Library
Mediators of the initiation, development, and recurrence of periodontitis include the oral
microbiome embedded in subgingival plaque and the host immune response to a dysbiosis …

An experimental framework for quantifying bacterial tolerance

A Brauner, N Shoresh, O Fridman, NQ Balaban - Biophysical journal, 2017 - cell.com
Antibiotic tolerance and persistence are often associated with treatment failure and relapse,
yet are poorly characterized. In distinction from resistance, which is measured using the …