Loss of cellular homeostasis during aging results in altered tissue functions and leads to a
general decline in fitness and, ultimately, death. As animals age, the control of gene …

Metabolomics is the latest 'omics' technology and systems biology science that allows for
comprehensive profiling of small-molecule metabolites in biological systems at a specific …

Physiological homeostasis becomes compromised during ageing, as a result of impairment
of cellular processes, including transcription and RNA splicing,,–. However, the molecular …

Ageing is driven by a loss of transcriptional and protein homeostasis,, and is the key risk
factor for multiple chronic diseases. Interventions that attenuate or reverse systemic …

Aging is characterized by the accumulation of proteins that display amyloid-like behavior.
However, the molecular mechanisms by which these proteins arise remain unclear. Here …

Accurate transcription is required for the faithful expression of genetic information. To
understand the molecular mechanisms that control the fidelity of transcription, we used novel …

Old age is associated with a progressive decline of mitochondrial function and changes in
nuclear chromatin. However, little is known about how metabolic activity and epigenetic …

To maintain proteostasis, cells must integrate information and activities that supervise
protein synthesis, protein folding, conformational stability, and also protein degradation …

We are facing a growing aging population, along with increasing pressure on health
systems, caused by the impact of chronic co‐morbidities (ie cancer, cardiovascular and …

Deleterious mutations are generally considered to be irrelevant for morphological evolution.
However, they could be compensated by conditionally beneficial mutations, thereby …