Seizures result from hypersynchronous, abnormal firing of neuronal populations and are the
primary clinical symptom of the epilepsies. Brain tissue from animal models and patients …

This review presents recent studies of the chemical and molecular regulators of
acetylcholine (ACh) signaling and the complexity of the small molecule and RNA regulators …

Alzheimer's disease (AD) is the most common age-related form of dementia, associated with
deposition of intracellular neuronal tangles consisting primarily of hyperphosphorylated …

There remains an urgent need for new therapies for treatment-resistant epilepsy. Sodium
channel blockers are effective for seizure control in common forms of epilepsy, but loss of …

MicroRNAs (miRNAs) have emerged as critical regulators of neuronal survival during
cerebral ischemia/reperfusion injury. Accumulating evidence has shown that miR-211 plays …

Temporal lobe epilepsy (TLE) is a chronic neurological disease in humans, which is
refractory to pharmacological treatment in about 30% of the patients. Reactive glial cells are …

Epilepsy is a severe, relapsing, and multifactorial neurological disorder. Studies regarding
the accurate diagnosis, prognosis, and in-depth pathogenesis are crucial for the precise and …

Ferroptosis is an iron-dependent cell death mechanism involving the accumulation of lipid
peroxides. As a critical regulator, glutathione peroxidase 4 (GPX4) has been demonstrated …

Canonical TGF-β signals are transduced from the cell surface to the cytoplasm, and then
translocated into the nucleus, a process that involves ligands (TGF-β1), receptors …

The short, non-coding RNAs, also called microRNAs (miRNAs) can bind complementary
sequences on cellular mRNAs. The consequence of this binding is generally the …