Wakefulness and vigilance levels are required for maintaining purposeful activities and
motivated behaviours, which are often triggered by sensory information conveying external …

Orexins (also known as hypocretins) are neuropeptides located exclusively in hypothalamic
neurons that have extensive projections throughout the central nervous system and bind two …

The hypocretins (H crts), also known as orexins, are two peptides derived from a single
precursor produced in the posterior lateral hypothalamus. Over the past decade, the orexin …

The orexin/hypocretin neuropeptide family has emerged as a focal point of neuroscientific
research following the discovery that this family plays a crucial role in a variety of …

The neuropeptides orexins are important in regulating the neurobiological systems that
respond to stressful stimuli. Furthermore, orexins are known to play a role many of the …

Orexins (hypocretins) are critically involved in coordinating appropriate physiological and
behavioral responses to aversive and threatening stimuli. Acute stressors engage orexin …

The neuropeptides orexins and their G protein-coupled receptors, OX1 and OX2, were
discovered in 1998, and since then, their role has been investigated in many functions …

The hypocretins/orexins are hypothalamic peptides most recognized for their significant
effects on feeding and arousal. Indeed, loss of the peptides results in a cataplexy quite …

In spite of significant progress in pharmacotherapy the incidence of newly diagnosed cases
of cardiovascular diseases and cardiovascular morbidity is alarmingly high. Treatment of …

Orexin‐expressing neurons in the hypothalamus project throughout the neuraxis and are
involved in regulation of the sleep/wake cycle, food intake, and autonomic functions. Here …