ML Ahmed, KK Ong, DB Dunger - Trends in Endocrinology & Metabolism, 2009 - cell.com
The potential relationship between childhood obesity and earlier puberty onset has major public health implications. Earlier menarche in girls is associated with increased risk of adult …
TM Plant - Frontiers in neuroendocrinology, 2015 - Elsevier
This chapter is based on the Geoffrey Harris Memorial Lecture presented at the 8th International Congress of Neuroendocrinology, which was held in Sydney, August 2014. It …
AP Abreu, CA Toro, YB Song… - The Journal of …, 2020 - Am Soc Clin Investig
The identification of loss-of-function mutations in MKRN3 in patients with central precocious puberty in association with the decrease in MKRN3 expression in the medial basal …
MJ Vazquez, CA Toro, JM Castellano… - Nature …, 2018 - nature.com
Puberty is regulated by epigenetic mechanisms and is highly sensitive to metabolic and nutritional cues. However, the epigenetic pathways mediating the effects of nutrition and …
SR Howard, L Dunkel - Endocrine reviews, 2019 - academic.oup.com
This review presents a comprehensive discussion of the clinical condition of delayed puberty, a common presentation to the pediatric endocrinologist, which may present both …
A Lomniczi, H Wright, SR Ojeda - Frontiers in Neuroendocrinology, 2015 - Elsevier
Substantial progress has been made in recent years toward deciphering the molecular and genetic underpinnings of the pubertal process. The availability of powerful new methods to …
S Leka-Emiri, GP Chrousos… - Journal of …, 2017 - Springer
Puberty is a major developmental stage. Damaging mutations, considered as “mistakes of nature”, have contributed to the unraveling of the networks implicated in the normal initiation …
SR Ojeda, C Dubay, A Lomniczi, G Kaidar… - Molecular and cellular …, 2010 - Elsevier
A sustained increase in pulsatile release of gonadotrophin releasing hormone (GnRH) from the hypothalamus is an essential, final event that defines the initiation of mammalian …
Interferon regulatory factor 2 binding protein-like (IRF2BPL) encodes a member of the IRF2BP family of transcriptional regulators. Currently the biological function of this gene is …