Kisspeptins and reproduction: physiological roles and regulatory mechanisms

L Pinilla, E Aguilar, C Dieguez, RP Millar… - Physiological …, 2012 - journals.physiology.org
Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …

Childhood obesity and the timing of puberty

ML Ahmed, KK Ong, DB Dunger - Trends in Endocrinology & Metabolism, 2009 - cell.com
The potential relationship between childhood obesity and earlier puberty onset has major
public health implications. Earlier menarche in girls is associated with increased risk of adult …

Neuroendocrine control of the onset of puberty

TM Plant - Frontiers in neuroendocrinology, 2015 - Elsevier
This chapter is based on the Geoffrey Harris Memorial Lecture presented at the 8th
International Congress of Neuroendocrinology, which was held in Sydney, August 2014. It …

MKRN3 inhibits the reproductive axis through actions in kisspeptin-expressing neurons

AP Abreu, CA Toro, YB Song… - The Journal of …, 2020 - Am Soc Clin Investig
The identification of loss-of-function mutations in MKRN3 in patients with central precocious
puberty in association with the decrease in MKRN3 expression in the medial basal …

SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression

MJ Vazquez, CA Toro, JM Castellano… - Nature …, 2018 - nature.com
Puberty is regulated by epigenetic mechanisms and is highly sensitive to metabolic and
nutritional cues. However, the epigenetic pathways mediating the effects of nutrition and …

Delayed puberty—phenotypic diversity, molecular genetic mechanisms, and recent discoveries

SR Howard, L Dunkel - Endocrine reviews, 2019 - academic.oup.com
This review presents a comprehensive discussion of the clinical condition of delayed
puberty, a common presentation to the pediatric endocrinologist, which may present both …

Epigenetic regulation of female puberty

A Lomniczi, H Wright, SR Ojeda - Frontiers in Neuroendocrinology, 2015 - Elsevier
Substantial progress has been made in recent years toward deciphering the molecular and
genetic underpinnings of the pubertal process. The availability of powerful new methods to …

The mystery of puberty initiation: genetics and epigenetics of idiopathic central precocious puberty (ICPP)

S Leka-Emiri, GP Chrousos… - Journal of …, 2017 - Springer
Puberty is a major developmental stage. Damaging mutations, considered as “mistakes of
nature”, have contributed to the unraveling of the networks implicated in the normal initiation …

Gene networks and the neuroendocrine regulation of puberty

SR Ojeda, C Dubay, A Lomniczi, G Kaidar… - Molecular and cellular …, 2010 - Elsevier
A sustained increase in pulsatile release of gonadotrophin releasing hormone (GnRH) from
the hypothalamus is an essential, final event that defines the initiation of mammalian …

IRF2BPL is associated with neurological phenotypes

PC Marcogliese, V Shashi, RC Spillmann… - The American Journal of …, 2018 - cell.com
Interferon regulatory factor 2 binding protein-like (IRF2BPL) encodes a member of the
IRF2BP family of transcriptional regulators. Currently the biological function of this gene is …