Tauopathies are classified according to whether tau deposits predominantly contain tau
isoforms with three or four repeats of the microtubule-binding domain. Those in which four …

Over 55 million people globally are living with dementia and, by 2050, this number is
projected to increase to 131 million. This poses immeasurable challenges for patients and …

Aims This study aimed to clarify the different topographical distribution of tau pathology
between progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) and …

Background Considering the wide range of outcomes following sport-related concussions,
biomarkers are needed to detect underlying pathological changes. The objective was to …

Objectives To evaluate the effect of Alzheimer's disease (AD)‐related biomarker change on
clinical features, brain atrophy and functional connectivity of patients with corticobasal …

These two complementary approaches obtained high diagnostic around 90% and above in
the classical Richardson form of PSP and probable MSA. Future work will determine if these …

Alzheimer's disease is defined by the presence of β-amyloid plaques and neurofibrillary tau
tangles potentially preceding clinical symptoms by many years. Previously only detectable …

Background The long-term consequences of concussions may include pathological
neurodegeneration as seen in Alzheimer's disease (AD) and chronic traumatic …

(1) Background: Frontotemporal lobar degeneration (FTLD) is a generic term which refers to
multiple pathologies, including FTLD-tau. The most common FTLD-tau diseases are Pick's …

Background Tau pathology plays a crucial role in neurodegeneration diseases including
Alzheimer's disease (AD) and non-AD diseases such as progressive supranuclear palsy …