Over several decades, various forms of genomic analysis of the human major
histocompatibility complex (MHC) have been extremely successful in picking up many …

Following primary infection, human cytomegalovirus (HCMV) establishes lifelong latency
and periodically reactivates without causing symptoms in healthy individuals. In the absence …

A systematic quantitative analysis of temporal changes in host and viral proteins throughout
the course of a productive infection could provide dynamic insights into virus-host …

During mouse cytomegalovirus (CMV) infection, a population of Ly49H+ natural killer (NK)
cells expands and is responsible for disease clearance through the induction of a “memory …

Infections with human cytomegalovirus (HCMV) are a major cause of morbidity and mortality
in humans with acquired or developmental deficits in innate and adaptive immunity. In the …

Human cytomegalovirus (HCMV) infection induces both innate immune responses including
Natural Killer cells as well as adaptive humoral and cell mediated (CD4+ helper, CD8+ …

NKG2D (natural-killer group 2, member D) is a powerful activating receptor expressed by
natural killer (NK) cells and T cells that regulates immune responses during infection, cancer …

Human cytomegalovirus (HCMV) in clinical material cannot replicate efficiently in vitro until it
has adapted by mutation. Consequently, wild-type HCMV differ fundamentally from the …

Major mechanisms for the recognition of pathogens by immune cells have evolved to
employ classical and non-classical major histocompatibility complex class I (MHC I) …

The MHC fold is found in proteins that have a range of functions in the maintenance of an
organism's health, from immune regulation to fat metabolism. Well adapted for antigen …