All multicellular organisms have mechanisms for killing their own cells, and use
physiological cell death for defence, development, homeostasis, and aging. Apoptosis is a …

The field of apoptosis is unusual in several respects. Firstly, its general importance has been
widely recognised only in the past few years and its surprising significance is still being …

In the accompanying paper by Weil et al.(1996) we show that staurosporine (STS), in the
presence of cycloheximide (CHX) to inhibit protein synthesis, induces apoptotic cell death in …

The cytoskeletal protein non-erythroid α-spectrin is well documented as an endogenous
calpain substrate, especially under pathophysiological conditions. In cell necrosis (eg …

The cyclin-dependent kinase inhibitor p21 Waf1/Cip1 is a downstream effector of the p53-
dependent cell growth arrest. We report herein that p21 was cleaved by caspase-3/CPP32 …

In the presence of cycloheximide (CHX) to inhibit protein synthesis, a high concentration of
staurosporine (STS) induces almost all cells in explant cultures of 8/8 types of newborn …

Chemotherapeutic agents that target topoisomerase I and II set into motion a series of
biochemical changes that culminate in cell death, but only under some conditions. The …

Abstract Interleukin-1β-converting enzyme (ICE)/ced-3 family proteases play key roles in
apoptosis. However, cellular substrates for ICE family proteases involved in apoptosis are …

Tumors result from the imbalance between cell growth and apoptosis. One of the
characteristic changes in cancers is the abnormality in cytoskeleton, which suggests some …

Pierre A. Henkart 1 scheme is consistent with the present data and the Experimental
Immunology Branch hypothesis that cytoplasmic proteases are part of the National Cancer …