Interaction of microglia and astrocytes in the neurovascular unit

L Liu, J Liu, J Bao, Q Bai, G Wang - Frontiers in immunology, 2020 - frontiersin.org
The interaction between microglia and astrocytes significantly influences neuroinflammation.
Microglia/astrocytes, part of the neurovascular unit (NVU), are activated by various brain …

Microglia-astrocyte crosstalk: an intimate molecular conversation

MK Jha, M Jo, JH Kim, K Suk - The Neuroscientist, 2019 - journals.sagepub.com
Microglia-astrocyte crosstalk has recently been at the forefront of glial research. Emerging
evidence illustrates that microglia-and astrocyte-derived signals are the functional …

Astrocytes: role and functions in brain pathologies

R Siracusa, R Fusco, S Cuzzocrea - Frontiers in Pharmacology, 2019 - frontiersin.org
Astrocytes are a population of cells with distinctive morphological and functional
characteristics that differ within specific areas of the brain. Postnatally, astrocyte progenitors …

Involvement of astrocytes in Alzheimer's disease from a neuroinflammatory and oxidative stress perspective

RE González-Reyes, MO Nava-Mesa… - Frontiers in molecular …, 2017 - frontiersin.org
Alzheimer disease (AD) is a frequent and devastating neurodegenerative disease in
humans, but still no curative treatment has been developed. Although many explicative …

[HTML][HTML] Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease

MD Turner, B Nedjai, T Hurst, DJ Pennington - Biochimica et Biophysica …, 2014 - Elsevier
Inflammation occurs as a result of exposure of tissues and organs to harmful stimuli such as
microbial pathogens, irritants, or toxic cellular components. The primary physical …

Spreading of pathology in neurodegenerative diseases: a focus on human studies

J Brettschneider, KD Tredici, VMY Lee… - Nature Reviews …, 2015 - nature.com
The progression of many neurodegenerative diseases is thought to be driven by the
template-directed misfolding, seeded aggregation and cell–cell transmission of …

Microglia–blood vessel interactions: a double-edged sword in brain pathologies

N Dudvarski Stankovic, M Teodorczyk, R Ploen… - Acta …, 2016 - Springer
Microglia are long-living resident immune cells of the brain, which secure a stable chemical
and physical microenvironment necessary for the proper functioning of the central nervous …

Role of redox signaling in neuroinflammation and neurodegenerative diseases

HL Hsieh, CM Yang - BioMed research international, 2013 - Wiley Online Library
Reactive oxygen species (ROS), a redox signal, are produced by various enzymatic
reactions and chemical processes, which are essential for many physiological functions and …

SARS-CoV-2 spike protein induces cognitive deficit and anxiety-like behavior in mouse via non-cell autonomous hippocampal neuronal death

J Oh, WH Cho, E Barcelon, KH Kim, J Hong, SJ Lee - Scientific reports, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is accompanied
by chronic neurological sequelae such as cognitive decline and mood disorder, but the …

Mitochondrial dynamics in SARS-COV2 spike protein treated human microglia: implications for neuro-COVID

E Clough, J Inigo, D Chandra, L Chaves… - Journal of Neuroimmune …, 2021 - Springer
Emerging clinical data from the current COVID-19 pandemic suggests that~ 40% of COVID-
19 patients develop neurological symptoms attributed to viral encephalitis while in COVID …