Gene delivery has revolutionized conventional medical approaches to vaccination, cancer,
and autoimmune diseases. However, current gene delivery methods are limited to either …

The homeostasis of cellular activities is essential for the normal functioning of living
organisms. Hence, the ability to regulate the fates of cells is of great significance for both …

Abstract Treatment with antibody drug conjugates targeting receptors over-expressed on
cancer cells is well established for clinical use in several types of cancer, however …

Simple Summary Drug conjugates, consisting of a tumor targeting part coupled to a highly
toxic molecule, are promising for treatment of many different types of cancer. However, for …

Site-selective, dual-conjugation approaches for the incorporation of distinct payloads are
key for the development of molecularly targeted biomolecules, such as antibody conjugates …

In the treatment of tumor-targeted small-molecule anti-cancer drugs, antibody-mediated
therapies, especially for antibody-drug conjugates (ADCs), have revealed great latent force …

Affibody molecules hold great promise as carriers of cytotoxic drugs for cancer therapy due
to their typically high affinity, easy production, and inherent control of the drug molecules' …

HER2 status determination is a necessary step for the proper choice of therapy and
selection of patients for the targeted treatment of cancer. Targeted radiotracers such as …

Targeted drug conjugates based on Affibody molecules fused to an albumin-binding domain
(ABD) for half-life extension have demonstrated potent anti-tumor activity in preclinical …

Human epidermal growth factor receptor 2 (HER2) is a clinically validated target for breast
cancer therapy. Previously, a drug-fused HER2-targeting affinity protein construct …