The chemokine receptor CXCR4 belongs to the large superfamily of G protein-coupled
receptors, and is directly involved in a number of biological processes including …

CC chemokine receptor 5 (CCR5) is a seven-transmembrane, G protein-coupled receptor
(GPCR) which regulates trafficking and effector functions of memory/effector T-lymphocytes …

Stem cell homing and breast cancer metastasis are orchestrated by the chemokine stromal
cell–derived factor 1 (SDF-1) and its receptor CXCR4. Here, we report the nuclear magnetic …

Chemokine receptor (CKR) signaling forms the basis of essential immune cellular functions,
and dysregulated CKR signaling underpins numerous disease processes of the immune …

Sulfated tyrosines at the amino terminus of the principal HIV-1 coreceptor CCR5 play a
critical role in its ability to bind the HIV-1 envelope glycoprotein gp120 and mediate HIV-1 …

Tyrosine sulfation is a post‐translational modification of secreted and transmembrane
proteins, including many GPCRs such as chemokine receptors. Most chemokine receptors …

Tyrosine sulfation of the chemokine receptor CXCR4 enhances its interaction with the
chemokine SDF-1α. Given similar post-translational modification of other receptors …

The human chemokine receptors, CCR5 and CXCR4, are potential host targets for
exogenous, small-molecule antagonists for the inhibition of HIV-1 infection. HIV-1 strains …

The chemokine RANTES (regulated upon activation, normal T-cell expressed and secreted)
is a natural ligand of CCR5, one of the major HIV-1 coreceptors. It is secreted as part of the …

Tyrosine sulfation, a post-translational modification, can determine and often enhance
protein–protein interaction specificity. Sulfotyrosyl residues (sTyrs) are formed by the …