Advances in research on pharmacotherapy of sarcopenia

Y Feike, L Zhijie, C Wei - Aging Medicine, 2021 - Wiley Online Library
Sarcopenia is a comprehensive degenerative disease with the progressive loss of skeletal
muscle mass with age, accompanied by the loss of muscle strength and muscle dysfunction …

Resveratrol and exercise combined to treat functional limitations in late life: a pilot randomized controlled trial

SA Harper, JR Bassler, S Peramsetty, Y Yang… - Experimental …, 2021 - Elsevier
Purpose To evaluate the safety and feasibility of combining exercise (EX) and resveratrol to
treat older adults with physical function limitations. Methods Three-arm, two-site pilot …

Sarcopenic obesity and hypertension in elderly patients: a narrative review of pathophysiology and management strategies

M Jurdana, L Žiberna - Annali dell'Istituto Superiore di Sanità, 2023 - annali.iss.it
Discussion. Given the lack of specific symptoms for sarcopenic obesity, early diagnosis and
management are crucial. Treatment strategies should prioritize weight loss, adequate …

Angiotensin (1–7) delivered orally via probiotic in combination with exercise: Sex-dependent influence on health span

A Hernandez, Y Sun, A Banerjee… - The Journals of …, 2023 - academic.oup.com
Age-related declines in physical and cognitive function can have tremendous, negative
impacts on health span and quality of life. Therefore, we investigated the potential of utilizing …

ACE I/D genotype associates with strength in sarcopenic men but not with response to ACE inhibitor therapy in older adults with sarcopenia: Results from the LACE …

C Rossios, T Bashir, M Achison, S Adamson, A Akpan… - Plos one, 2023 - journals.plos.org
Background Angiotensin II (AII), has been suggested to promote muscle loss. Reducing AII
synthesis, by inhibiting angiotensin converting enzyme (ACE) activity has been proposed as …

Effect of treatment with carvacrol and aerobic training on cardiovascular function in spontaneously hypertensive rats

HA Costa, CJM Dias, VA Martins… - Experimental …, 2021 - Wiley Online Library
New Findings What is the central question of this study? Can two non‐drug therapies,
carvacrol and aerobic physical training, together have additive effects on the reduction of …

Enalapril induces muscle epigenetic changes and contributes to prevent a decline in running capacity in spontaneously hypertensive rats

DC Dos Santos, FHF Alves, LF Veríssimo… - Archives of Gerontology …, 2025 - Elsevier
Drugs such as angiotensin-converting enzyme inhibitors and angiotensin receptor blockers
can improve muscle function and exercise capacity, as well as preventing, attenuating or …

Understanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in older adults: NIH NIA Workshop summary

ML Erickson, JM Allen, DP Beavers, LM Collins… - GeroScience, 2023 - Springer
Exercise is a cornerstone of preventive medicine and a promising strategy to intervene on
the biology of aging. Variation in the response to exercise is a widely accepted concept that …

Serum concentrations of losartan metabolites correlate with improved physical function in a pilot study of prefrail older adults

JL Lee, C Zhang, R Westbrook… - The Journals of …, 2022 - academic.oup.com
Losartan is an oral antihypertensive agent that is rapidly metabolized to EXP3174
(angiotensin-subtype-1-receptor blocker) and EXP3179 (peroxisome proliferator-activated …

Interactive effects of enalapril administration and novel HIIT wheel-bed training in aged rats

Y Yang, A Banerjee, Y Sun, CS Carter… - Frontiers in rehabilitation …, 2021 - frontiersin.org
Introduction: Growing research suggests that aerobic high-intensity interval training (HIIT)
improves cardiovascular function and physical performance compared with moderate …