Background The insulin-like growth factor family of ligands (IGF-I, IGF-II, and insulin),
receptors (IGF-IR, M6P/IGF-IIR, and insulin receptor [IR]), and IGF-binding proteins (IGFBP-1 …

The prevalence and incidence of type 2 diabetes (T2D) among the Hispanic population in
the United States are higher than the national average. This is partly due to sociocultural …

Abstract The Mexico City Prospective Study is a prospective cohort of more than 150,000
adults recruited two decades ago from the urban districts of Coyoacán and Iztapalapa in …

The insulin-like growth factor (IGF) system comprises two ligands, IGF-I and IGF-II, that
regulate multiple physiological processes, including mammalian development, metabolism …

Genome-wide association studies have implicated around 250 genomic regions in
predisposition to type 2 diabetes, with evidence for causal variants and genes emerging for …

Identification of the genes and processes mediating genetic association signals for complex
diseases represents a major challenge. As many of the genetic signals for type 2 diabetes …

Type 2 diabetes is more common in non‐Europeans and starts at a younger age and at
lower BMI cut‐offs. This review discusses the insights from genetic studies about …

Numerous studies have shown that oxidative stress resulting from an imbalance between
the production of free radicals and their neutralization by antioxidant enzymes is one of the …

When originally discovered, one of the initial observations was that, when all of the insulin
peptide was depleted from serum, the vast majority of the insulin activity remained and this …

Context Type 2 diabetes mellitus (T2DM) and cancer share a variety of risk factors and
pathophysiological features. It is becoming increasingly accepted that the 2 diseases are …