Lipidomics aims to quantitatively define lipid classes, including their molecular species, in
biological systems. Lipidomics has experienced rapid progress, mainly because of …

Mitochondrial-derived vesicles (MDVs) are implicated in diverse physiological processes—
for example, mitochondrial quality control—and are linked to various neurodegenerative …

Autophagy is a conserved catabolic homeostasis process central for cellular and organismal
health. During autophagy, small single-membrane phagophores rapidly expand into large …

Lysosomes serve dual antagonistic functions in cells by mediating anabolic growth signaling
and the catabolic turnover of macromolecules. How these janus-faced activities are …

Skeletal muscle accumulates ceramides in obesity, which contribute to the development of
obesity-associated insulin resistance. However, it remained unclear which distinct ceramide …

Double membrane vesicles (DMVs) serve as replication organelles of plus-strand RNA
viruses such as hepatitis C virus (HCV) and SARS-CoV-2. Viral DMVs are morphologically …

Mutations in OPA1 cause autosomal dominant optic atrophy (DOA) as well as DOA+, a
phenotype characterized by more severe neurological deficits. OPA1 deficiency causes …

The acyl-CoA synthetase 4 (ACSL4) has been implicated in carcinogenesis and neuronal
development. Acyl-CoA synthetases are essential enzymes of lipid metabolism, and ACSL4 …

Polymers can facilitate detergent-free extraction of membrane proteins into nanodiscs (eg,
SMALPs, DIBMALPs), incorporating both integral membrane proteins as well as co …

Mitochondria are central for cellular metabolism and energy supply. Barth syndrome (BTHS)
is a severe disorder, due to dysfunction of the mitochondrial cardiolipin acyl transferase …