[HTML][HTML] Neural substrates of depression and resilience

MH Han, EJ Nestler - Neurotherapeutics, 2017 - Elsevier
There is an urgent need for more effective medications to treat major depressive disorder, as
fewer than half of depressed patients achieve full remission and many are not responsive …

[HTML][HTML] Noradrenergic modulation of stress resilience

X Zhai, D Zhou, Y Han, MH Han, H Zhang - Pharmacological Research, 2023 - Elsevier
Resilience represents an active adaption process in the face of adversity, trauma, tragedy,
threats, or significant sources of stress. Investigations of neurobiological mechanisms of …

α1-and β3-adrenergic receptor–mediated mesolimbic homeostatic plasticity confers resilience to social stress in susceptible mice

H Zhang, D Chaudhury, AR Nectow, AK Friedman… - Biological …, 2019 - Elsevier
Background Homeostatic plasticity in mesolimbic dopamine (DA) neurons plays an essential
role in mediating resilience to social stress. Recent evidence implicates an association …

Sex differences in the neuroadaptations of reward-related circuits in response to subchronic variable stress

S Zhang, H Zhang, SM Ku, B Juarez, C Morel… - Neuroscience, 2018 - Elsevier
Women are twice as likely to be diagnosed with major depressive disorder. However, fewer
studies in rodent models of depression have used female animals, leading to a relative lack …

Molecular, cellular, and circuit basis of depression susceptibility and resilience

MH Han, SJ Russo, EJ Nestler - Neurobiology of depression, 2019 - Elsevier
Prolonged stressful events are an important risk factor for major depressive disorder.
However, there are dramatic individual variations in response to stress: a relatively small …

[图书][B] The role of the locus coeruleus-noradrenergic system in resilience to foot-shock stress

C Guinaudie - 2018 - search.proquest.com
Background: Post-traumatic stress disorder (PTSD) is caused by exposure to extreme
traumatic stress and is characterised by intrusive fear-related memories, hyper-arousal and …