M Mahar, V Cavalli - Nature Reviews Neuroscience, 2018 - nature.com
Permanent disabilities following CNS injuries result from the failure of injured axons to regenerate and rebuild functional connections with their original targets. By contrast, injury …
JM Griffin, F Bradke - EMBO molecular medicine, 2020 - embopress.org
The recent years saw the advent of promising preclinical strategies that combat the devastating effects of a spinal cord injury (SCI) that are progressing towards clinical trials …
Injured peripheral nerves regenerate their lost axons but functional recovery in humans is frequently disappointing. This is so particularly when injuries require regeneration over long …
KJ Zuo, T Gordon, KM Chan, GH Borschel - Experimental neurology, 2020 - Elsevier
Peripheral nerve injuries are common and frequently result in incomplete functional recovery even with optimal surgical treatment. Permanent motor and sensory deficits are …
Spinal cord injury (SCI) is a devastating condition that causes severe loss of motor, sensory and autonomic functions. Additionally, many individuals experience chronic neuropathic …
T Gordon, AW English - European Journal of Neuroscience, 2016 - Wiley Online Library
Enhancing the regeneration of axons is often considered to be a therapeutic target for improving functional recovery after peripheral nerve injury. In this review, the evidence for …
M Zhou, M Huang, H Zhong, C Xing… - Advanced Functional …, 2022 - Wiley Online Library
Peripheral nerve injuries represent one of the most common causes of permanent disabilities. Therapeutic electrical stimulation has been widely used in neural regeneration …
K Liu, A Tedeschi, KK Park, Z He - Annual review of …, 2011 - annualreviews.org
Failure of axon regeneration after central nervous system (CNS) injuries results in permanent functional deficits. Numerous studies in the past suggested that blocking …
MP Willand, MA Nguyen… - … and neural repair, 2016 - journals.sagepub.com
Peripheral nerve injury afflicts individuals from all walks of life. Despite the peripheral nervous system's intrinsic ability to regenerate, many patients experience incomplete …