Autophagy modulation in cancer therapy: challenges coexist with opportunities

Y Wu, A Wang, G Feng, X Pan, W Shuai, P Yang… - European Journal of …, 2024 - Elsevier
Autophagy, a crucial intracellular degradation process facilitated by lysosomes, plays a
pivotal role in maintaining cellular homeostasis. The elucidation of autophagy key genes …

Trace elements and metal nanoparticles: mechanistic approaches to mitigating chemotherapy-induced toxicity—a review of literature evidence

AC Famurewa, MY George, CA Ukwubile, S Kumar… - BioMetals, 2024 - Springer
Anticancer chemotherapy (ACT) remains a cornerstone in cancer treatment, despite
significant advances in pharmacology over recent decades. However, its associated side …

The Molecular Mechanism of Yam Polysaccharide Protected H2O2-Induced Oxidative Damage in IEC-6 Cells

M Shen, R Cai, Z Li, X Chen, J Xie - Foods, 2023 - mdpi.com
Oxidative stress is involved in maintaining homeostasis of the body, and an in-depth study of
its mechanism of action is beneficial for the prevention of chronic illnesses. This study aimed …

Uro-protective role of chrysin against cyclophosphamide-induced hemorrhagic cystitis in rats involving the turning-off NF-κB/P38-MAPK, NO/PARP-1 and STAT-3 …

DO Saleh, NMEA El-Nasr, AM Fayez, KA Ahmed… - Chemico-Biological …, 2023 - Elsevier
Background Chemotherapeutic agents are used to treat a wide range of cancer types, but
they cause serious side effects which must be managed after treatment. Cyclophosphamide …

Sildenafil improves radiation‐induced oral mucositis by attenuating oxidative stress, NF‐κB, ERK and JNK signalling pathways

M Ala, R Mohammad Jafari, M Ala… - Journal of Cellular …, 2022 - Wiley Online Library
Radiation‐induced oral mucositis is a common and dose‐limiting complication of head and
neck radiotherapy with no effective treatment. Previous studies revealed that sildenafil, a …

Carbon Dots with Integrated Photothermal Antibacterial and Heat‐Enhanced Antioxidant Properties for Diabetic Wound Healing

H Wang, S Sun, Y Zhao, P Wang, Y Zhou, H Sun… - Small, 2024 - Wiley Online Library
Diabetic wounds pose a persistent challenge due to their slow healing nature, primarily
caused by bacterial infection and excessive reactive oxygen species (ROS)‐induced …

Immune-Enhancing Effects of Co-treatment With Kalopanax pictus Nakai Bark and Nelumbo nucifera Gaertner Leaf Extract in a Cyclophosphamide-Induced …

YM Park, HY Lee, DY Shin, DS Kim, JJ Yoo… - Frontiers in …, 2022 - frontiersin.org
Objective Immune system disorders can result in various pathological conditions, such as
infections and cancer. Identifying therapies that enhance the immune response might be …

Histological study of the role of CD34+ stem cells and mast cells in cyclophosphamide-induced thymic injury in rats and the possible attenuating role of melatonin

AI Shrief, WHE Hamed, SA Mazroa… - Histochemistry and Cell …, 2023 - Springer
Cyclophosphamide (CP) is an anticancer drug that adversely affects immunity and thymus
structure. Melatonin is a hormone secreted by the pineal gland. It boosts immunity and has …

[HTML][HTML] Nano-TiO2 regulates the MAPK (ERK, P38) pathway to promote apoptosis and inhibit proliferation of human colon cells

Z Xiao, M Zheng, J Deng, Y Shi, M Jia, W Li - … and Environmental Safety, 2024 - Elsevier
Abstract Background Nano titanium dioxides (TiO 2) are widely used in drug development,
food additives and packaging materials. Although several studies have demonstrated the …

Determinants of placental insufficiency in fetal growth restriction.

A Dall'Asta, C Melito, G Morganelli… - … in Obstetrics & …, 2023 - search.ebscohost.com
Abstract CPM-I and CPM-II have been shown to have little or no impact on fetal growth,
while CPM-III has been associated with preterm birth, small-for-gestational-age newborns …