Introduction: Relapses are important contributors to illness and morbidity in Plasmodium
vivax and P. ovale infections. Relapse prevention (radical cure) with primaquine is required …

Primaquine is the only antimalarial drug available to clinicians for the treatment of relapsing
forms of malaria. Primaquine development and usage dates back to the 1940s and has …

Primaquine (PQ) is an essential antimalarial drug but despite being developed over 70
years ago, its mode of action is unclear. Here, we demonstrate that hydroxylated-PQ …

Background Radical cure of Plasmodium vivax malaria with 8-aminoquinolines (primaquine
or tafenoquine) is complicated by haemolysis in individuals with glucose-6-phosphate …

The eradication of malaria will only be possible if effective, well-tolerated medicines kill
hypnozoites in vivax and ovale malaria, and thus prevent relapses in patients. Despite …

Primaquine (PQ) metabolism by the cytochrome P450 (CYP) 2D family of enzymes is
required for antimalarial activity in both humans (2D6) and mice (2D). Human CYP 2D6 is …

Background Eradication of malaria is difficult because of the ability of hypnozoite, the
dormant liver-stage form of Plasmodium vivax, to cause relapse in patients. Research efforts …

Abstract Background Primaquine (PQ), an 8-aminoquinoline, is the only drug approved by
the United States Food and Drug Administration for radical cure and prevention of relapse in …

Analytical methods for the quantification of the new 8-aminoquinoline antimalarial
tafenoquine (TQ) in human blood, plasma and urine, and the 5, 6-orthoquinone tafenoquine …

Apd1, a cytosolic yeast protein, and Aim32, its counterpart in the mitochondrial matrix, have
a C-terminal thioredoxin-like ferredoxin (TLF) domain and a widely divergent N-terminal …