ACE2 receptor polymorphism: Susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome

CA Devaux, JM Rolain, D Raoult - Journal of Microbiology, Immunology …, 2020 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged in
Chinese people in December 2019 and has currently spread worldwide causing the COVID …

COVID-19, renin-angiotensin system and endothelial dysfunction

R Amraei, N Rahimi - Cells, 2020 - mdpi.com
The newly emergent novel coronavirus disease 2019 (COVID-19) outbreak, which is caused
by SARS-CoV-2 virus, has posed a serious threat to global public health and caused …

Mechanisms of cisplatin-induced acute kidney injury: pathological mechanisms, pharmacological interventions, and genetic mitigations

KR McSweeney, LK Gadanec, T Qaradakhi, BA Ali… - Cancers, 2021 - mdpi.com
Simple Summary Nephrotoxicity is the dose-limiting factor of cisplatin treatment.
Nephrotoxicity is characterized by reduced kidney function. Although an often-reversible …

[HTML][HTML] The ACE2/angiotensin-(1–7)/MAS axis of the renin-angiotensin system: focus on angiotensin-(1–7)

RAS Santos, WO Sampaio, AC Alzamora… - Physiological …, 2017 - journals.physiology.org
The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular
system and hydroelectrolyte balance, with an influence on organs and functions throughout …

SARS-CoV-2, ACE2 expression, and systemic organ invasion

UM Ashraf, AA Abokor, JM Edwards… - Physiological …, 2021 - journals.physiology.org
A novel coronavirus disease, COVID-19, has created a global pandemic in 2020, posing an
enormous challenge to healthcare systems and affected communities. COVID-19 is caused …

COVID-19 and cardiovascular consequences: Is the endothelial dysfunction the hardest challenge?

S Del Turco, A Vianello, R Ragusa, C Caselli… - Thrombosis research, 2020 - Elsevier
Abstract A Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) has become
a pandemic disease named Coronavirus Disease-19 (COVID-19) of epochal dimension …

Angiotensin-converting enzyme 2 (ACE2): COVID 19 gate way to multiple organ failure syndromes

M Kuppusamy, W Wankhar, KR Gurugubelli… - Respiratory physiology …, 2021 - Elsevier
Background Globally, the current medical emergency for novel coronavirus 2019 (COVID-
19) leads to respiratory distress syndrome and death. Purpose This review highlighted the …

ACE2 in brain physiology and pathophysiology: evidence from transgenic animal models

N Alenina, M Bader - Neurochemical research, 2019 - Springer
Abstract Angiotensin-converting enzyme 2 (ACE2) is a protein consisting of two domains,
the N-terminus is a carboxypeptidase homologous to ACE and the C-terminus is …

Mechanisms of COVID-19-induced kidney injury and current pharmacotherapies

WH Faour, A Choaib, E Issa, FE Choueiry… - Inflammation …, 2022 - Springer
The COVID-19 pandemic created a worldwide debilitating health crisis with the entire
humanity suffering from the deleterious effects associated with the high infectivity and …

The potential actions of angiotensin‐converting enzyme II (ACE2) activator diminazene aceturate (DIZE) in various diseases

T Qaradakhi, LK Gadanec… - Clinical and …, 2020 - Wiley Online Library
The renin angiotensin system (RAS) regulates fluid balance, blood pressure and maintains
vascular tone. The potent vasoconstrictor angiotensin II (Ang II) produced by angiotensin …