Clinical actionability of molecular targets in endometrial cancer

ME Urick, DW Bell - Nature Reviews Cancer, 2019 - nature.com
Abstract Endometrial cancer accounts for~ 76,000 deaths among women each year
worldwide. Disease mortality and the increasing number of new diagnoses make …

Precise subcellular organelle targeting for boosting endogenous‐stimuli‐mediated tumor therapy

W Zhen, S An, S Wang, W Hu, Y Li, X Jiang… - Advanced …, 2021 - Wiley Online Library
Though numerous external‐stimuli‐triggered tumor therapies, including phototherapy,
radiotherapy, and sonodynamic therapy have made great progress in cancer therapy, the …

Engineering nanosystems to overcome barriers to cancer diagnosis and treatment

SO Alhaj-Suliman, EI Wafa, AK Salem - Advanced drug delivery reviews, 2022 - Elsevier
Over the past two decades, multidisciplinary investigations into the development of
nanoparticles for medical applications have continually increased. However, nanoparticles …

Advances in synthetic lethality for cancer therapy: cellular mechanism and clinical translation

W Topatana, S Juengpanich, S Li, J Cao, J Hu… - Journal of hematology & …, 2020 - Springer
Synthetic lethality is a lethal phenomenon in which the occurrence of a single genetic event
is tolerable for cell survival, whereas the co-occurrence of multiple genetic events results in …

Quantitative assessment of nanoparticle biodistribution by fluorescence imaging, revisited

F Meng, J Wang, Q Ping, Y Yeo - ACS nano, 2018 - ACS Publications
Fluorescence-based whole-body imaging is widely used in the evaluation of nanoparticles
(NPs) in small animals, often combined with quantitative analysis to indicate their …

Nanomedicines inhibiting tumor metastasis and recurrence and their clinical applications

X Kong, R Cheng, J Wang, Y Fang, KC Hwang - Nano Today, 2021 - Elsevier
Tumor metastasis and recurrence is one of the biggest problems in curing cancers. Due to
the difficulty in complete removal of the primary tumor in traditional surgeries and the poor …

Nanoparticle-based delivery of CRISPR/Cas9 genome-editing therapeutics

BE Givens, YW Naguib, SM Geary, EJ Devor… - The AAPS journal, 2018 - Springer
The recent progress in harnessing the efficient and precise method of DNA editing provided
by CRISPR/Cas9 is one of the most promising major advances in the field of gene therapy …

Design of Astaxanthin-Loaded Core–Shell Nanoparticles Consisting of Chitosan Oligosaccharides and Poly(lactic-co-glycolic acid): Enhancement of Water Solubility …

C Liu, S Zhang, DJ McClements… - Journal of agricultural …, 2019 - ACS Publications
Astaxanthin, a hydrophobic carotenoid found in marine plants and animals, is claimed to
exhibit various beneficial biological activities. Its use as a nutraceutical in foods, however, is …

Enhanced cellular uptake and cytotoxicity of vorinostat through encapsulation in TPGS-modified liposomes

MA Farooq, H Xinyu, A Jabeen, A Ahsan… - Colloids and Surfaces B …, 2021 - Elsevier
Vorinostat (VOR) is known as one of the histone deacetylase inhibitors (HDACi) for cancer
treatment, and the FDA approves it for cutaneous T cell lymphoma therapy. Poor solubility …

Exploration of the natural active small-molecule drug-loading process and highly efficient synergistic antitumor efficacy

J Wang, H Zhao, K Zhi, X Yang - ACS applied materials & …, 2020 - ACS Publications
The development and application of nano-drug carriers might provide an excellent
opportunity for cancer therapy. However, it is still an important challenge to realize the …