Drugs with low water solubility are predisposed to poor and variable oral bioavailability and,
therefore, to variability in clinical response, that might be overcome through an appropriate …

The unique and frequently beautiful morphologies that characterize many biominerals have
long been a source of fascination. While research began by looking first at individual …

It is now just about 10 years since the publication of the first edition of Polymorphism in
Pharmaceutical Solids, which certainly received a positive reaction from workers in drug …

Amorphous solid dispersion (ASD) is one of the most effective approaches for delivering
poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs …

The concepts of high-throughput (HT) screening and combinatorial synthesis have been
integrated into the pharmaceutical discovery process, but are not yet commonplace in the …

Biomimetic mineralization is a powerful approach for the synthesis of advanced materials
with complex shape, hierarchical organization and controlled size, shape and polymorph …

The diversity of solid-state forms that an active pharmaceutical ingredient (API) may attain
relies on the repertoire of non-covalent interactions and molecular assemblies, the range of …

Within the pharmaceutical industry, and elsewhere, the screening for new solid forms is a
mandatory exercise for both existing and new chemical entities. This contribution focuses on …

For decades, carbamazepine (CBZ) has served as a model compound for groups engaged
in the study of crystal polymorphism. Despite considerable effort, crystal structures for only …

Chemical compounds that exist in multiple crystalline forms are said to exhibit
polymorphism. Polymorphs have the same composition, but their structures and properties …