Background: Levels of atherogenic lipoproteins achieved with statin therapy are highly
variable, but the consequence of this variability for cardiovascular disease risk is not well …

Background Atorvastatin is one of the most widely prescribed drugs and the most widely
prescribed statin in the world. It is therefore important to know the dose‐related magnitude of …

Purpose In this study we characterized the genetic variability of 146 clinically relevant genes
influencing drug pharmacokinetics in African and European subpopulations, which are key …

Objectives: We sought to identify single nucleotide polymorphisms associated with mild
statin-induced side effects. Background: Statin-induced side effects can interfere with …

Molecular diagnostics, the use of diagnostic testing to understand the molecular
mechanisms of an individual patient's disease, will be pivotal in the delivery of safe and …

Background and aims Many patients treated with statins are considered statin-resistant
because they fail to achieve adequate reduction of low density lipoprotein cholesterol (LDL …

We previously conducted genome-wide association meta-analysis of systolic blood
pressure, diastolic blood pressure, and hypertension in 29 136 people from 6 cohort studies …

Elevated levels of low‐density lipoprotein cholesterol (LDL‐C) in plasma are a major
contributor to cardiovascular disease, which is the leading cause of death worldwide …

This study was undertaken to uncover the regulatory role of lycopene in targeting
lipopolysaccharide (LPS) induced oxidative stress and inflammatory cascades and …

Reduced levels of HDL cholesterol (HDL-C) are a strong independent predictor of coronary
artery disease (CAD) risk. The major anti-atherogenic function of HDL is to mediate reverse …