The rapid emergence of antifungal-resistant human-pathogenic fungi

SR Lockhart, A Chowdhary, JAW Gold - Nature Reviews Microbiology, 2023 - nature.com
During recent decades, the emergence of pathogenic fungi has posed an increasing public
health threat, particularly given the limited number of antifungal drugs available to treat …

Marine-Derived Metabolites Act as Promising Antifungal Agents

S Hang, H Lu, Y Jiang - Marine Drugs, 2024 - mdpi.com
The incidence of invasive fungal diseases (IFDs) is on the rise globally, particularly among
immunocompromised patients, leading to significant morbidity and mortality. Current clinical …

Co-Delivery of a High Dose of Amphotericin B and Itraconazole by Means of a Dry Powder Inhaler Formulation for the Treatment of Severe Fungal Pulmonary …

SS Celi, R Fernández-García, AI Afonso-Urich… - Pharmaceutics, 2023 - mdpi.com
Over the past few decades, there has been a considerable rise in the incidence and
prevalence of pulmonary fungal infections, creating a global health problem due to a lack of …

[HTML][HTML] Accelerating the understanding of Aspergillus terreus: Epidemiology, physiology, immunology and advances

R Thakur, SK Shishodia, A Sharma, A Chauhan… - Current Research in …, 2024 - Elsevier
Aspergillus species encompass a variety of infections, ranging from invasive aspergillosis to
allergic conditions, contingent upon the immune status of the host. In this spectrum …

Drug-Resistant Aspergillus spp.: A Literature Review of Its Resistance Mechanisms and Its Prevalence in Europe

MA De Francesco - Pathogens, 2023 - mdpi.com
Infections due to the Aspergillus species constitute an important challenge for human health.
Invasive aspergillosis represents a life-threatening disease, mostly in patients with immune …

Fungi involved in rhinosinusitis in arid regions: insights from molecular identification and antifungal susceptibility

S Zhou, MAI Ismail, JB Buil, A Gabr… - Microbiology …, 2023 - Am Soc Microbiol
Fungal rhinosinusitis (FRS) is a common problem worldwide, with an increasing burden in
arid climate regions. Aspergillus species are the most common causative agents involved. In …

Unveiling environmental transmission risks: comparative analysis of azole resistance in Aspergillus fumigatus clinical and environmental isolates from Yunnan, China

J Gong, J Huang, Y Liu, Y Zhang, Y Gao - Microbiology Spectrum, 2024 - journals.asm.org
Azole resistance in Aspergillus fumigatus poses a significant clinical challenge globally. Our
previous epidemiological analysis revealed a remarkably high frequency (~ 80%) of azole …

Sphingosine as a New Antifungal Agent against Candida and Aspergillus spp.

F Hashemi Arani, S Kadow, M Kramer… - International Journal of …, 2022 - mdpi.com
This study investigated whether sphingosine is effective as prophylaxis against Aspergillus
spp. and Candida spp. In vitro experiments showed that sphingosine is very efficacious …

Do morphogenetic switching and intraspecies variation enhance virulence of Candida auris?

T Phan-Canh, K Kuchler - Plos Pathogens, 2024 - journals.plos.org
Intraspecies variations that affect pathogenicity and antifungal resistance traits pose a
serious obstacle to efficient therapy of Candida auris infections. Recent reports indicate that …

Lipid-Like Biofilm from a Clinical Brain Isolate of Aspergillus terreus: Quantification, Structural Characterization and Stages of the Formation Cycle

G Rayón-López, N Carapia-Minero… - Mycopathologia, 2023 - Springer
Invasive infections caused by filamentous fungi have increased considerably due to the
alteration of the host's immune response. Aspergillus terreus is considered an emerging …