HLA variation and antigen presentation in COVID-19 and SARS-CoV-2 infection
DG Augusto, JA Hollenbach - Current opinion in immunology, 2022 - Elsevier
Highlights•Variation in both HLA and SARS-CoV-2 impact antigen presentation to T
cells.•HLA variation influences COVID-19 outcomes and T-cell responses to SARS-CoV …
cells.•HLA variation influences COVID-19 outcomes and T-cell responses to SARS-CoV …
[HTML][HTML] Advances in the evolutionary understanding of MHC polymorphism
Proteins encoded by the classical major histocompatibility complex (MHC) genes incite the
vertebrate adaptive immune response by presenting peptide antigens on the cell surface …
vertebrate adaptive immune response by presenting peptide antigens on the cell surface …
Thinking about the evolution of complex traits in the era of genome-wide association studies
Many traits of interest are highly heritable and genetically complex, meaning that much of
the variation they exhibit arises from differences at numerous loci in the genome. Complex …
the variation they exhibit arises from differences at numerous loci in the genome. Complex …
A genomic perspective on HLA evolution
Several decades of research have convincingly shown that classical human leukocyte
antigen (HLA) loci bear signatures of natural selection. Despite this conclusion, many …
antigen (HLA) loci bear signatures of natural selection. Despite this conclusion, many …
Binding affinities of 438 HLA proteins to complete proteomes of seven pandemic viruses and distributions of strongest and weakest HLA peptide binders in …
We report detailed peptide‐binding affinities between 438 HLA Class I and Class II proteins
and complete proteomes of seven pandemic human viruses, including coronaviruses …
and complete proteomes of seven pandemic human viruses, including coronaviruses …
Relating pathogenic loss-of-function mutations in humans to their evolutionary fitness costs
Causal loss-of-function (LOF) variants for Mendelian and severe complex diseases are
enriched in'mutation intolerant'genes. We show how such observations can be interpreted in …
enriched in'mutation intolerant'genes. We show how such observations can be interpreted in …
Detecting long-term balancing selection using allele frequency correlation
KM Siewert, BF Voight - Molecular biology and evolution, 2017 - academic.oup.com
Balancing selection occurs when multiple alleles are maintained in a population, which can
result in their preservation over long evolutionary time periods. A characteristic signature of …
result in their preservation over long evolutionary time periods. A characteristic signature of …
Transcriptional adaptation: a mechanism underlying genetic robustness
TE Sztal, DYR Stainier - Development, 2020 - journals.biologists.com
Mutations play a crucial role in evolution as they provide the genetic variation that allows
evolutionary change. Although some mutations in regulatory elements or coding regions can …
evolutionary change. Although some mutations in regulatory elements or coding regions can …
What has GWAS done for HLA and disease associations?
AE Kennedy, U Ozbek, MT Dorak - International journal of …, 2017 - Wiley Online Library
The major histocompatibility complex (MHC) is located in chromosome 6p21 and contains
crucial regulators of immune response, including human leucocyte antigen (HLA) genes …
crucial regulators of immune response, including human leucocyte antigen (HLA) genes …
Pathogen diversity drives the evolution of generalist MHC-II alleles in human populations
Central players of the adaptive immune system are the groups of proteins encoded in the
major histocompatibility complex (MHC), which shape the immune response against …
major histocompatibility complex (MHC), which shape the immune response against …