The changing paradigm of intron retention: regulation, ramifications and recipes
Intron retention (IR) is a form of alternative splicing that has long been neglected in
mammalian systems although it has been studied for decades in non-mammalian species …
mammalian systems although it has been studied for decades in non-mammalian species …
RNA-binding proteins control gene expression and cell fate in the immune system
M Turner, MD Díaz-Muñoz - Nature immunology, 2018 - nature.com
RNA-binding proteins (RBPs) are essential for the development and function of the immune
system. They interact dynamically with RNA to control its biogenesis and turnover by …
system. They interact dynamically with RNA to control its biogenesis and turnover by …
[HTML][HTML] TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A
Variants of UNC13A, a critical gene for synapse function, increase the risk of amyotrophic
lateral sclerosis and frontotemporal dementia,–, two related neurodegenerative diseases …
lateral sclerosis and frontotemporal dementia,–, two related neurodegenerative diseases …
Exon architecture controls mRNA m6A suppression and gene expression
N 6-methyladenosine (m6A) is the most abundant messenger RNA (mRNA) modification
and plays crucial roles in diverse physiological processes. Using a massively parallel assay …
and plays crucial roles in diverse physiological processes. Using a massively parallel assay …
METTL16 exerts an m6A-independent function to facilitate translation and tumorigenesis
METTL16 has recently been identified as an RNA methyltransferase responsible for the
deposition of N 6-methyladenosine (m6A) in a few transcripts. Whether METTL16 methylates …
deposition of N 6-methyladenosine (m6A) in a few transcripts. Whether METTL16 methylates …
[HTML][HTML] Intron retention is a source of neoepitopes in cancer
AC Smart, CA Margolis, H Pimentel, MX He… - Nature …, 2018 - nature.com
We present an in silico approach to identifying neoepitopes derived from intron retention
events in tumor transcriptomes. Using mass spectrometry immunopeptidome analysis, we …
events in tumor transcriptomes. Using mass spectrometry immunopeptidome analysis, we …
[HTML][HTML] Nascent RNA scaffolds contribute to chromosome territory architecture and counter chromatin compaction
KM Creamer, HJ Kolpa, JB Lawrence - Molecular cell, 2021 - cell.com
Nuclear chromosomes transcribe far more RNA than required to encode protein. Here we
investigate whether non-coding RNA broadly contributes to cytological-scale chromosome …
investigate whether non-coding RNA broadly contributes to cytological-scale chromosome …
[HTML][HTML] PRMT5 inhibition disrupts splicing and stemness in glioblastoma
Glioblastoma (GBM) is a deadly cancer in which cancer stem cells (CSCs) sustain tumor
growth and contribute to therapeutic resistance. Protein arginine methyltransferase 5 …
growth and contribute to therapeutic resistance. Protein arginine methyltransferase 5 …
An alternative splicing variant of PtRD26 delays leaf senescence by regulating multiple NAC transcription factors in Populus
HL Wang, Y Zhang, T Wang, Q Yang, Y Yang… - The Plant …, 2021 - academic.oup.com
During leaf senescence, the final stage of leaf development, nutrients are recycled from
leaves to other organs, and therefore proper control of senescence is thus critical for plant …
leaves to other organs, and therefore proper control of senescence is thus critical for plant …
[HTML][HTML] Dissecting the causal mechanism of X-linked dystonia-parkinsonism by integrating genome and transcriptome assembly
Summary X-linked Dystonia-Parkinsonism (XDP) is a Mendelian neurodegenerative
disease that is endemic to the Philippines and is associated with a founder haplotype. We …
disease that is endemic to the Philippines and is associated with a founder haplotype. We …