Chemotherapy remains the most important means of controlling malaria, one of the
deadliest infectious parasitic diseases in the world. Antimalarial antifolates have been …

This document was prepared for the Roll Back Malaria Department of the World Health
Organization by Pascal Ringwald with the collaboration of Laura Shallcross, who was …

The antifolate sulphadoxine-pyrimethamine (SP) has been used in the intermittent
prevention of malaria in pregnancy (IPTp). SP is an ideal choice for IPTp, however, as …

Selection of resistant malaria strains occurs when parasites are exposed to inadequate
antimalarial drug concentrations. The proportion of uncomplicated falciparum malaria …

Resistance to chloroquine (CQ) in Plasmodium falciparum has reached unacceptably high
levels in many endemic countries. The pre-treatment factors that identify the children who …

The inhibition or disruption of folate metabolism remains an attractive target for the discovery
of new antimalarial drugs. The importance of this pathway was proved in the 1940s with the …

In vitro pyrimethamine response of Plasmodium falciparum isolates and dihydrofolate
reductase (dhfr) gene sequences were analyzed in 2004–2005 and compared with our …

The burgeoning problem of drug resistance in malaria requires the urgent discovery of new
drugs. Discovery of an antimalarial agent that fulfills the requirements of a mass-treatment …

The prevalence of pyrimethamine–sulfadoxine (PS)-resistant Plasmodium falciparum
malaria has been increasing in sub-Saharan Africa or other parts of the world in the last one …

Selection of resistant malaria strains occurs when parasites are exposed to inadequate
antimalarial drug concentrations. The proportion of uncomplicated falciparum malaria …