Dendritic cells are powerful antigen-presenting cells that are essential for the priming of T
cell responses. In addition to providing T-cell-receptor ligands and co-stimulatory molecules …

Pseudomonas aeruginosa is a key pathogen of chronic infections in the lungs of cystic
fibrosis patients and in patients suffering from chronic wounds of diverse etiology. In these …

The signals driving the adaptation of type 2 dendritic cells (DC2s) to diverse peripheral
environments remain mostly undefined. We show that differentiation of CD11blo migratory …

The phenotypic and functional dichotomy between IRF8+ type 1 and IRF4+ type 2
conventional dendritic cells (cDC1s and cDC2s, respectively) is well accepted; it is unknown …

Dendritic cells (DCs) are critical for the activation of naïve CD4+ T cells and are considered
professional antigen-presenting cells (APCs), as are macrophages and B cells. Recently …

Type 2 immune responses operate under varying conditions in distinct tissue environments
and are crucial for protection against helminth infections and for the maintenance of tissue …

Group 2 innate lymphoid cells (ILC2s) are important effector cells driving the initiation of type
2 immune responses leading to adaptive T helper 2 (Th2) immunity. Here we show that …

Numerous species of nematodes have evolved to inhabit the gastrointestinal tract of animals
and humans, with over a billion of the world's population infected with at least one species …

Polarized T helper cell (Th cell) responses are important determinants of host protection. Th
cell subsets tailor their functional repertoire of cytokines to their cognate antigens to …

Abstract T-helper 2 (Th2) cell responses defend against parasites. Although dendritic cells
(DCs) are vital for the induction of T-cell responses, the DC subpopulations that induce Th2 …