The essential elements of Alzheimer's disease

P Lei, S Ayton, AI Bush - Journal of Biological Chemistry, 2021 - ASBMB
Treatments for Alzheimer's disease (AD) directed against the prominent amyloid plaque
neuropathology are yet to be proved effective despite many phase 3 clinical trials. There are …

Detection, identification, and quantification of oxidative protein modifications

CL Hawkins, MJ Davies - Journal of Biological Chemistry, 2019 - ASBMB
Exposure of biological molecules to oxidants is inevitable and therefore commonplace.
Oxidative stress in cells arises from both external agents and endogenous processes that …

ROS and RNS signalling: adaptive redox switches through oxidative/nitrosative protein modifications

NT Moldogazieva, IM Mokhosoev… - Free radical …, 2018 - Taylor & Francis
Over the last decade, a dual character of cell response to oxidative stress, eustress versus
distress, has become increasingly recognized. A growing body of evidence indicates that …

Molecular mechanisms and genetics of oxidative stress in Alzheimer's disease

F Cioffi, RHI Adam, K Broersen - Journal of Alzheimer's …, 2019 - content.iospress.com
Alzheimer's disease is the most common neurodegenerative disorder that can cause
dementia in elderly over 60 years of age. One of the disease hallmarks is oxidative stress …

Effects of in vivo conditions on amyloid aggregation

MC Owen, D Gnutt, M Gao, SKTS Wärmländer… - Chemical Society …, 2019 - pubs.rsc.org
One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …

Effect of atmospheric cold plasma on structure, interfacial and emulsifying properties of Grass pea (Lathyrus sativus L.) protein isolate

HM Mehr, A Koocheki - Food Hydrocolloids, 2020 - Elsevier
Abstract Structure and emulsifying properties of Grass pea (Lathyrus sativus) protein isolate
(GPPI) were investigated as function of cold plasma treatment at two voltages (9.4 and 18.6 …

Oxidative crosslinking of peptides and proteins: Mechanisms of formation, detection, characterization and quantification

E Fuentes-Lemus, P Hägglund, C López-Alarcón… - Molecules, 2021 - mdpi.com
Covalent crosslinks within or between proteins play a key role in determining the structure
and function of proteins. Some of these are formed intentionally by either enzymatic or …

Programming Delayed Dissolution Into Sacrificial Bioinks For Dynamic Temporal Control of Architecture within 3D‐Bioprinted Constructs

BG Soliman, A Longoni, M Wang, W Li… - Advanced Functional …, 2023 - Wiley Online Library
Sacrificial printing allows introduction of architectural cues within engineered tissue
constructs. This strategy adopts the use of a 3D‐printed sacrificial ink that is embedded …

Redox role of ROS and inflammation in pulmonary diseases

L Zuo, D Wijegunawardana - Lung Inflammation in Health and Disease …, 2021 - Springer
Reactive oxygen species (ROS), either derived from exogenous sources or overproduced
endogenously, can disrupt the body's antioxidant defenses leading to compromised redox …

Enzymatic and non-enzymatic crosslinks found in collagen and elastin and their chemical synthesis

J Gaar, R Naffa, M Brimble - Organic Chemistry Frontiers, 2020 - pubs.rsc.org
Collagen and elastin are the most abundant structural proteins in animals and play an
integral biological and structural role in the extracellular matrix. The biosynthesis and …