Histone posttranslational modifications represent a versatile set of epigenetic marks
involved not only in dynamic cellular processes, such as transcription and DNA repair, but …

Histone modifications are thought to regulate chromatin structure, transcription and other
nuclear processes. Histone methylation was originally believed to be an irreversible …

In the past few years, it has become clear that mutations in epigenetic regulatory genes are
common in human cancers. Therapeutic strategies are now being developed to target …

Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …

Recent studies on mutations in cancer genomes have distinguished driver mutations from
passenger mutations, which occur as byproducts of cancer development. The cancer …

It has recently been demonstrated that the genes controlling the epigenetic programmes that
are required for maintaining chromatin structure and cell identity include genes that drive …

The chromatin environment is modulated by a machinery of chromatin modifiers, required for
the specification and maintenance of cell fate. Many mutations in the machinery have been …

Resistance of cancer cells to chemotherapeutics and emerging targeted drugs is a
devastating problem in the treatment of cancer patients. Multiple mechanisms contribute to …

The occurrence of cancer entails a series of genetic mutations that favor uncontrollable
tumor growth. It is believed that various factors collectively contribute to cancer, and there is …

Post-translational modification of histones provides an important regulatory platform for
processes such as gene expression, DNA replication and repair, chromosome condensation …