Optimizing CAR-T cell therapy for solid tumors: current challenges and potential strategies

K Ai, B Liu, X Chen, C Huang, liping Yang… - Journal of Hematology & …, 2024 - Springer
Chimeric antigen receptor (CAR)-T cell therapy demonstrates substantial efficacy in various
hematological malignancies. However, its application in solid tumors is still limited. Clinical …

Advancing genome editing with artificial intelligence: opportunities, challenges, and future directions

S Dixit, A Kumar, K Srinivasan… - … in Bioengineering and …, 2024 - frontiersin.org
Clustered regularly interspaced short palindromic repeat (CRISPR)-based genome editing
(GED) technologies have unlocked exciting possibilities for understanding genes and …

[HTML][HTML] Artificial intelligence in cancer care: From diagnosis to prevention and beyond

M Farrokhi, A Moeini, F Taheri, M Farrokhi, M Mostafavi… - Kindle, 2023 - preferpub.org
Artificial Intelligence (AI) has made significant strides in revolutionizing cancer care,
encompassing various aspects from diagnosis to prevention and beyond. With its ability to …

[HTML][HTML] AI and Deep Learning in Understanding the Etiology and Pathogenesis of Cancers

P Nemati, A Khalaji, Y Rajabloo, MH Kazemi, S Nouri… - Kindle, 2024 - preferpub.org
Artificial intelligence (AI) and deep learning have emerged as powerful tools in
understanding the etiology and pathogenesis of cancers. These technologies help uncover …

Biodrug Delivery Systems: Do mRNA Lipid Nanoparticles Come of Age?

M Puccetti, A Schoubben, S Giovagnoli… - International Journal of …, 2023 - mdpi.com
As an appealing alternative to treat and prevent diseases ranging from cancer to COVID-19,
mRNA has demonstrated significant clinical effects. Nanotechnology facilitates the …

Personalized Medicine in Pancreatic Cancer: The Promise of Biomarkers and Molecular Targeting with Dr. Michael J. Pishvaian

V Cortiana, RH Abbas, H Chorya, J Gambill… - Cancers, 2024 - mdpi.com
Simple Summary Pancreatic cancer, with its increasing incidence, is predicted to become
the second deadliest solid tumor by 2040, urging for improved diagnostic and treatment …

The transformative potential of AI-driven CRISPR-Cas9 genome editing to enhance CAR T-cell therapy

A Boretti - Computers in Biology and Medicine, 2024 - Elsevier
This narrative review examines the promising potential of integrating artificial intelligence
(AI) with CRISPR-Cas9 genome editing to advance CAR T-cell therapy. AI algorithms offer …

Preclinical Anticipation of On-and Off-Target Resistance Mechanisms to Anti-Cancer Drugs: A Systematic Review

PJ Dziubańska-Kusibab, E Nevedomskaya… - International Journal of …, 2024 - mdpi.com
The advent of targeted therapies has led to tremendous improvements in treatment options
and their outcomes in the field of oncology. Yet, many cancers outsmart precision drugs by …

Precision oncology revolution: CRISPR-Cas9 and PROTAC technologies unleashed

K Kanbar, R El Darzi, DE Jaalouk - Frontiers in Genetics, 2024 - frontiersin.org
Cancer continues to present a substantial global health challenge, with its incidence and
mortality rates persistently reflecting its significant impact. The emergence of precision …

Applications of CRISPR Technology to Breast Cancer and Triple Negative Breast Cancer Research

M Pont, M Marqués, MA Sorolla, E Parisi, I Urdanibia… - Cancers, 2023 - mdpi.com
Simple Summary The technique of Clustered Regularly Interspaced Short Palindromic
Repeats (CRISPR) has revolutionised cancer research, including breast cancer and triple …