Exosomes: potential disease biomarkers and new therapeutic targets
Exosomes are extracellular vesicles released by cells, both constitutively and after cell
activation, and are present in different types of biological fluid. Exosomes are involved in the …
activation, and are present in different types of biological fluid. Exosomes are involved in the …
[HTML][HTML] Cognitive epigenetic priming: leveraging histone acetylation for memory amelioration
Highlights•Learning naturally enhances histone acetylation in the hippocampus.•Cognitive
impairments hinder increased acetylation during learning.•HDACi enhances acetylation and …
impairments hinder increased acetylation during learning.•HDACi enhances acetylation and …
A microRNA signature that correlates with cognition and is a target against cognitive decline
While some individuals age without pathological memory impairments, others develop age‐
associated cognitive diseases. Since changes in cognitive function develop slowly over time …
associated cognitive diseases. Since changes in cognitive function develop slowly over time …
A combined miRNA–piRNA signature to detect Alzheimer's disease
Alzheimer's disease (AD) is the most common neurodegenerative disorder causing huge
emotional and economic burden to our societies. An effective therapy has not been …
emotional and economic burden to our societies. An effective therapy has not been …
[HTML][HTML] An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene
A growing number of epigenome-wide association studies have demonstrated a role for
DNA methylation in the brain in Alzheimer's disease. With the aim of exploring peripheral …
DNA methylation in the brain in Alzheimer's disease. With the aim of exploring peripheral …
Mouse models of neurodegeneration: Know your question, know your mouse
EMC Fisher, DM Bannerman - Science translational medicine, 2019 - science.org
Many mutant mouse strains have been developed as models to investigate
neurodegenerative disease in humans. However, variability in results among studies using …
neurodegenerative disease in humans. However, variability in results among studies using …
Current understanding of fear learning and memory in humans and animal models and the value of a linguistic approach for analyzing fear learning and memory in …
Fear is an emotion that serves as a driving factor in how organisms move through the world.
In this review, we discuss the current understandings of the subjective experience of fear …
In this review, we discuss the current understandings of the subjective experience of fear …
Update on neurobiological mechanisms of fear: illuminating the direction of mechanism exploration and treatment development of trauma and fear-related disorders
Y Li, W Zhi, B Qi, L Wang, X Hu - Frontiers in Behavioral …, 2023 - frontiersin.org
Fear refers to an adaptive response in the face of danger, and the formed fear memory acts
as a warning when the individual faces a dangerous situation again, which is of great …
as a warning when the individual faces a dangerous situation again, which is of great …
[HTML][HTML] Multiple roles of the actin and microtubule-regulating formins in the developing brain
KK Galbraith, M Kengaku - Neuroscience Research, 2019 - Elsevier
Dynamic control of the actin and microtubule cytoskeletons underlie nearly every critical
process during neural development, and requires multiple dimensions of regulation …
process during neural development, and requires multiple dimensions of regulation …
Molecular linkage between post-traumatic stress disorder and cognitive impairment: a targeted proteomics study of World Trade Center responders
Existing work on proteomics has found common biomarkers that are altered in individuals
with post-traumatic stress disorder (PTSD) and mild cognitive impairment (MCI). The current …
with post-traumatic stress disorder (PTSD) and mild cognitive impairment (MCI). The current …