Big Data bring new opportunities to modern society and challenges to data scientists. On the
one hand, Big Data hold great promises for discovering subtle population patterns and …

Alzheimer's disease (AD) affects an estimated 44 million individuals worldwide, yet no
therapeutic intervention is available to stop the progression of the dementia …

Cancer cachexia is a metabolic syndrome that can be present even in the absence of weight
loss ('precachexia'). Cachexia is often compounded by pre-existing muscle loss, and is …

Neuroinflammation is initiated when glial cells, mainly microglia, are activated by threats to
the neural environment, such as pathogen infiltration or neuronal injury. Although …

Osteoarthritis (OA), the most common rheumatic disease, is characterized by joint-space
narrowing due to progressive cartilage degradation and alterations in subchondral bone …

Glial activation participates in the mediation of pain including neuropathic pain, due to
release of neuroexcitatory, proinflammatory products. Glial activation is now known to occur …

Several sesquiterpene lactones are the active components of several medicinal plants and
have been demonstrated to perform various pharmacological functions. In this study, we …

The nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing
protein 3 (NLRP3) inflammasome is an important regulator of inflammation and immune …

Early recognition of invading bacteria by the innate immune system has a crucial function in
antibacterial defense by triggering inflammatory responses that prevent the spread of …

Clinacanthus nutans has had a long history of use in folk medicine in Malaysia and
Southeast Asia; mostly in the relief of inflammatory conditions. In this study, we investigated …