Many cellular functions are regulated by calcium (Ca2+) signals that are generated by
different signaling pathways. One of these is the inositol 1, 4, 5-trisphosphate/calcium …

Epilepsy is a common brain disorder, characterized by spontaneous recurrent seizures, with
associated neuropsychiatric and cognitive comorbidities and increased mortality. Although …

The most common forms of acquired epilepsies arise following acute brain insults such as
traumatic brain injury, stroke, or central nervous system infections. Treatment is effective for …

Synapses are essential components of neurons and allow information to travel coordinately
throughout the nervous system to adjust behavior to environmental stimuli and to control …

Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are prominent regulators
of neuronal survival, growth and differentiation during development. While trophic factors are …

Epilepsy is a group of chronic neurological disorders that have diverse etiologies but are
commonly characterized by spontaneous seizures and behavioral comorbidities. Although …

We recently discovered that forebrain activation of the IL-1 receptor/Toll-like receptor (IL-
1R1/TLR4) innate immunity signal plays a pivotal role in neuronal hyperexcitability …

Epilepsy involves neuronal dysfunction at molecular, cellular, and circuit levels. The
understanding of the mechanism of the epilepsies has advanced greatly in the last three …

ObjectiveEpilepsy is a chronic neurological disease characterised with seizures. The
aetiology of the most generalised epilepsies cannot be explicitly determined and the …

Traumatic brain injury (TBI) and status epilepticus (SE) have both been linked to
development of human epilepsy. Although distinct etiologies, current research has …