Strategies for the development of metalloimmunotherapies
Metal ions play crucial roles in the regulation of immune pathways. In fact, metallodrugs
have a long record of accomplishment as effective treatments for a wide range of diseases …
have a long record of accomplishment as effective treatments for a wide range of diseases …
Metalloimmunology: The metal ion-controlled immunity
Metals are essential components in all forms of life required for the function of nearly half of
all enzymes and are critically involved in virtually all fundamental biological processes …
all enzymes and are critically involved in virtually all fundamental biological processes …
The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability
Alpha-synuclein (αS) is a conformationally plastic protein that reversibly binds to cellular
membranes. It aggregates and is genetically linked to Parkinson's disease (PD). Here, we …
membranes. It aggregates and is genetically linked to Parkinson's disease (PD). Here, we …
Manganese salts function as potent adjuvants
Aluminum-containing adjuvants have been used for nearly 100 years to enhance immune
responses in billions of doses of vaccines. To date, only a few adjuvants have been …
responses in billions of doses of vaccines. To date, only a few adjuvants have been …
[HTML][HTML] Exosome-inflammasome crosstalk and their roles in inflammatory responses
C Noonin, V Thongboonkerd - Theranostics, 2021 - ncbi.nlm.nih.gov
Inflammasome is a complex of multiple proteins found in cytoplasm of the cells activated by
infectious and/or non-infectious stimuli. This complex involves caspase-1 activation, leading …
infectious and/or non-infectious stimuli. This complex involves caspase-1 activation, leading …
Manganese-induced neurotoxicity: new insights into the triad of protein misfolding, mitochondrial impairment, and neuroinflammation
DS Harischandra, S Ghaisas, G Zenitsky… - Frontiers in …, 2019 - frontiersin.org
Occupational or environmental exposure to manganese (Mn) can lead to the development of
“Manganism,” a neurological condition showing certain motor symptoms similar to …
“Manganism,” a neurological condition showing certain motor symptoms similar to …
Mitochondrial dysfunction as a driver of NLRP3 inflammasome activation and its modulation through mitophagy for potential therapeutics
The NLR family pyrin domain containing 3 (NLRP3) inflammasome is responsible for the
sensation of various pathogenic and non-pathogenic damage signals and has a vital role in …
sensation of various pathogenic and non-pathogenic damage signals and has a vital role in …
Genetic and environmental factors in Alzheimer's and Parkinson's diseases and promising therapeutic intervention via fecal microbiota transplantation
H Wang, F Yang, S Zhang, R Xin, Y Sun - npj Parkinson's Disease, 2021 - nature.com
Neurodegenerative diseases are characterized by neuronal impairment and loss of function,
and with the major shared histopathological hallmarks of misfolding and aggregation of …
and with the major shared histopathological hallmarks of misfolding and aggregation of …
INT-777 attenuates NLRP3-ASC inflammasome-mediated neuroinflammation via TGR5/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats
X Hu, J Yan, L Huang, C Araujo, J Peng, L Gao… - Brain, behavior, and …, 2021 - Elsevier
Background Inflammasome-mediated neuroinflammation plays an important role in the
pathogenesis of early brain injury (EBI) following subarachnoid hemorrhage (SAH). The …
pathogenesis of early brain injury (EBI) following subarachnoid hemorrhage (SAH). The …
Kv1. 3 modulates neuroinflammation and neurodegeneration in Parkinson's disease
Characterization of the key cellular targets contributing to sustained microglial activation in
neurodegenerative diseases, including Parkinson's disease (PD), and optimal modulation of …
neurodegenerative diseases, including Parkinson's disease (PD), and optimal modulation of …