[PDF][PDF] Depression's multiple comorbidities explained by (neuro) inflammatory and oxidative & nitrosative stress pathways

M Maes, M Kubera, E Obuchowiczwa… - Neuroendocrinol …, 2011 - researchgate.net
There is now evidence that depression, as characterized by melancholic symptoms, anxiety,
and fatigue and somatic (F&S) symptoms, is the clinical expression of peripheral cell …

Oxidative stress and DNA damage: implications in inflammatory bowel disease

C Pereira, D Grácio, JP Teixeira… - Inflammatory bowel …, 2015 - academic.oup.com
This review will focus on published human studies on oxidative stress and DNA damage in
inflammatory bowel disease (IBD), both ulcerative colitis and Crohn's disease, assessing …

Regulation of intestinal inflammation by dietary fats

AR Basson, C Chen, F Sagl, A Trotter… - Frontiers in …, 2021 - frontiersin.org
With the epidemic of human obesity, dietary fats have increasingly become a focal point of
biomedical research. Epidemiological studies indicate that high-fat diets (HFDs), especially …

Amentoflavone inhibits iNOS, COX-2 expression and modulates cytokine profile, NF-κB signal transduction pathways in rats with ulcerative colitis

KM Sakthivel, C Guruvayoorappan - International immunopharmacology, 2013 - Elsevier
Ulcerative colitis is a chronic inflammatory disorder characterized by oxidative stress,
leucocyte infiltration and upregulation of pro-inflammatory cytokines. The aim of the present …

Apolipoprotein AI mimetics mitigate intestinal inflammation in a COX2-dependent inflammatory disease model

D Meriwether, D Sulaiman, C Volpe… - The Journal of …, 2019 - Am Soc Clin Investig
Cyclooxygenase 2 (Cox2) total knockout and myeloid knockout (MKO) mice develop Crohn's-
like intestinal inflammation when fed cholate-containing high-fat diet (CCHF). We …

Different profile of peripheral antioxidant enzymes and lipid peroxidation in active and non-active inflammatory bowel disease patients

D Achitei, A Ciobica, G Balan, E Gologan… - Digestive diseases and …, 2013 - Springer
Background The role of oxidative stress in inflammatory bowel diseases (IBD) has been
extended lately from a simple consequence of inflammation to a potential etiological factor …

Insights into diet-associated oxidative pathomechanisms in inflammatory bowel disease and protective effects of functional amino acids

Y Ji, Y Yang, S Sun, Z Dai, F Ren, Z Wu - Nutrition Reviews, 2023 - academic.oup.com
There has been a substantial rise in the incidence and prevalence of clinical patients
presenting with inflammatory bowel disease (IBD), which includes Crohn's disease and …

Melatonin and inflammatory bowel disease: From basic mechanisms to clinical application

M Vaghari-Tabari, S Moein, A Alipourian, D Qujeq… - Biochimie, 2023 - Elsevier
Inflammatory bowel disease is a chronic inflammatory disease and has periods of
recurrence and remission. Improper immune responses to gut flora bacteria, along with …

Protective effect of 6-paradol in acetic acid-induced ulcerative colitis in rats

M Rafeeq, HAS Murad, HM Abdallah… - … medicine and therapies, 2021 - Springer
Background Ulcerative colitis is a gut inflammatory disorder due to altered immune response
to gut microbiome, with interplay of environmental and genetic factors. TNF-α activates …

Roles of lipid peroxidation-derived electrophiles in pathogenesis of colonic inflammation and colon cancer

L Lei, J Zhang, EA Decker, G Zhang - Frontiers in Cell and …, 2021 - frontiersin.org
Redox stress is a common feature of gut disorders such as colonic inflammation
(inflammatory bowel disease or IBD) and colorectal cancer (CRC). This leads to increased …