Potential role of oxidative stress in the pathogenesis of diabetic bladder dysfunction

QX Song, Y Sun, K Deng, JY Mei… - Nature Reviews …, 2022 - nature.com
Diabetes mellitus is a chronic metabolic disease, posing a considerable threat to global
public health. Treating systemic comorbidities has been one of the greatest clinical …

Inflammation triggered by the NLRP3 inflammasome is a critical driver of diabetic bladder dysfunction

FM Hughes Jr, MR Odom, A Cervantes… - Frontiers in …, 2022 - frontiersin.org
Diabetes is a rapidly expanding epidemic projected to affect as many as 1 in 3 Americans by
2050. This disease is characterized by devastating complications brought about high …

[HTML][HTML] Pathophysiology of the underactive bladder

N Aizawa, Y Igawa - Investigative and Clinical Urology, 2017 - synapse.koreamed.org
Underactive bladder (UAB), which has been described as a symptom complex suggestive of
detrusor underactivity, is usually characterized by prolonged urination time with or without a …

Videourodynamic studies of women with voiding dysfunction

SM Hsiao, HH Lin, HC Kuo - Scientific Reports, 2017 - nature.com
This retrospective study is aimed to present videourodynamic findings of women with
symptoms of voiding dysfunction in a medical center. Of 1914 women, the diagnoses …

Voiding dysfunction due to detrusor underactivity: an overview

MJ Drake, J Williams, DA Bijos - Nature Reviews Urology, 2014 - nature.com
Detrusor underactivity (DUA) is defined as a voiding contraction of reduced strength and/or
duration, which prolongs urination and/or prevents complete emptying of the bladder within …

Grape seed proanthocyanidin extract ameliorates diabetic bladder dysfunction via the activation of the Nrf2 pathway

S Chen, Y Zhu, Z Liu, Z Gao, B Li, D Zhang, Z Zhang… - PLoS …, 2015 - journals.plos.org
Diabetes Mellitus (DM)-induced bladder dysfunction is predominantly due to the long-term
oxidative stress caused by hyperglycemia. Grape seed proanthocyanidin extract (GSPE) has …

Antagonism of proNGF or its receptor p75NTR reverses remodelling and improves bladder function in a mouse model of diabetic voiding dysfunction

AH Mossa, A Galan, PG Cammisotto… - Diabetologia, 2020 - Springer
Aims/hypothesis Although 80% of diabetic patients will suffer from voiding difficulties and
urinary symptoms, defined as diabetic voiding dysfunction (DVD), therapeutic targets and …

Urethral striated muscle and extracellular matrix morphological characteristics among mildly diabetic pregnant rats: translational approach

F Piculo, G Marini, AMP Barbosa… - International …, 2014 - Springer
Introduction and hypothesis Diabetes mellitus (DM) during pregnancy is associated with
high levels of urinary incontinence (UI) and pelvic floor muscle dysfunction. Mild DM can …

Rac1 as a Target to Treat Dysfunctions and Cancer of the Bladder

V Sauzeau, J Beignet, C Bailly - Biomedicines, 2022 - mdpi.com
Bladder pathologies, very common in the aged population, have a considerable negative
impact on quality of life. Novel targets are needed to design drugs and combinations to treat …

Lower urinary tract symptoms in women with diabetes mellitus: a current review

R James, A Hijaz - Current urology reports, 2014 - Springer
A literature review of the most current publications studying lower urinary tract symptoms
(LUTS) and findings in diabetic women was conducted including articles from January 2013 …