Increasing attention has been paid to the diseases of central nervous system (CNS). The
penetration efficiency of most CNS drugs into the brain parenchyma is rather limited due to …

In recent years, nanomedicines have emerged as a promising method for central nervous
system drug delivery, enabling the drugs to overcome the blood-brain barrier and …

Glioma is a primary aggressive brain tumor with high recurrence rate. The poor efficiency of
chemotherapeutic drugs crossing the blood‒brain barrier (BBB) is well-known as one of the …

Abstract Treatment of malignant glioma is a challenge facing cancer therapy. In addition to
surgery, and chemotherapy, radiotherapy (RT) is one of the most effective modalities of …

The poor prognosis and rapid recurrence of glioblastoma (GB) are associated to its fast-
growing process and invasive nature, which make difficult the complete removal of the …

Abstract Blood-Brain Barrier (BBB) is one of the most important physiological barriers strictly
restricting the substance exchange between blood and brain tissues. While the BBB protects …

The integrin α v β 3 receptor and Lactoferrin receptor (LfR) are over-expressed in both
cerebral microvascular endothelial cells and glioma cells. RGD tripeptide and Lf can …

A successful drug delivery to a specific site relies on two essential factors including; efficient
entrapment of the drug within the carrier and successful delivery of drug-loaded nanocarrier …

EGFR TKI therapy has become a first-line regimen for non-small cell lung cancer (NSCLC)
patients with EGRF mutations. However, there are two big challenges against effective …

Abstract Herein, lactoferrin (Lf)/phenylboronic acid (PBA)-functionalized hyaluronic acid
nanogels crosslinked with disulfide-bond crosslinker was developed as a reduction …