Quinoline: a promising antitubercular target

RS Keri, SA Patil - Biomedicine & Pharmacotherapy, 2014 - Elsevier
Tuberculosis (TB) remains a global public health problem in recent years. TB originated
mainly from various strains of Mycobacterium tuberculosis, is a highly infectious and chronic …

Quinoline‐derivatives as privileged scaffolds for medicinal and pharmaceutical chemists: A comprehensive review

V Yadav, J Reang, V Sharma, J Majeed… - Chemical Biology & …, 2022 - Wiley Online Library
The quinoline scaffolds are privileged for their numerous biological activities in the
pharmaceutical field. This moiety constitutes a well‐known space in several marketed …

New quinoline derivatives: Synthesis and investigation of antibacterial and antituberculosis properties

S Eswaran, AV Adhikari, IH Chowdhury, NK Pal… - European journal of …, 2010 - Elsevier
Four new series of quinoline derivatives were synthesized starting from 2-trifluoromethyl
aniline through multi-step reactions. In the reaction sequence, substituted aniline was …

Synthesis and identification of β-aryloxyquinolines and their pyrano [3, 2-c] chromene derivatives as a new class of antimicrobial and antituberculosis agents

DC Mungra, MP Patel, DP Rajani, RG Patel - European journal of medicinal …, 2011 - Elsevier
A new class of β-aryloxyquinolines 3a–i and their pyrano [3, 2-c] chromene derivatives 6a–r
incorporating a validated molecular target has been synthesized via a nucleophilic …

Design, synthesis and docking studies of new quinoline-3-carbohydrazide derivatives as antitubercular agents

KD Thomas, AV Adhikari, S Telkar… - European journal of …, 2011 - Elsevier
Three new series of 4-hydroxy-8-trifluoromethyl-quinoline derivatives were synthesized
through multi step reactions. All the newly synthesized compounds were characterized by …

Cascade reaction of isatins with 1, 1-enediamines: Synthesis of multisubstituted quinoline-4-carboxamides

BQ Wang, CH Zhang, XX Tian, J Lin, SJ Yan - Organic letters, 2018 - ACS Publications
A one-step methodology for the synthesis of multisubstituted quinoline-4-carboxamides was
developed by simply refluxing a mixture of isatins 1 and various kinds of 1, 1-enediamines 2 …

Cascade reaction of isatins with heterocyclic ketene aminals: Synthesis of imidazopyrroloquinoline derivatives

F Yu, S Yan, L Hu, Y Wang, J Lin - Organic Letters, 2011 - ACS Publications
A concise and efficient route for the synthesis of highly substituted imidazopyrroloquinoline
derivatives by simply refluxing a reaction mixture of different types of isatins and heterocyclic …

Quinoline and quinolones: promising scaffolds for future antimycobacterial agents

S Singh, G Kaur, V Mangla… - Journal of enzyme …, 2015 - Taylor & Francis
Tuberculosis (TB) is still a major health concern worldwide. The increasing incidences of
multi-drug-resistant tuberculosis (MDR-TB) necessitate the development of new anti-TB …

Design, synthesis and anticancer evaluation of new substituted thiophene-quinoline derivatives

DIA Othman, KB Selim, AA Magda, AS Tantawy… - Bioorganic & Medicinal …, 2019 - Elsevier
A series of new isoxazolyl, triazolyl and phenyl based 3-thiophen-2-yl-quinoline derivatives
were synthesized adopting click chemistry approach. In addition, the synthesis of new useful …

[HTML][HTML] Synthesis, docking studies, and in vitro evaluation of some novel thienopyridines and fused thienopyridine–quinolines as antibacterial agents and DNA …

EM Mohi El-Deen, EA Abd El-Meguid, S Hasabelnaby… - Molecules, 2019 - mdpi.com
A series of novel thienopyridines and pyridothienoquinolines (3a, b–14) was synthesized,
starting with 2-thioxo-1, 2-dihydropyridine-3-carbonitriles 1a and 1b. All compounds were …