[HTML][HTML] Anandamide and other N-acylethanolamines: A class of signaling lipids with therapeutic opportunities
Abstract N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …
A large-scale genome-wide association study meta-analysis of cannabis use disorder
Background Variation in liability to cannabis use disorder has a strong genetic component
(estimated twin and family heritability about 50–70%) and is associated with negative …
(estimated twin and family heritability about 50–70%) and is associated with negative …
Anti-inflammatory ω-3 endocannabinoid epoxides
DR McDougle, JE Watson… - Proceedings of the …, 2017 - National Acad Sciences
Clinical studies suggest that diets rich in ω-3 polyunsaturated fatty acids (PUFAs) provide
beneficial anti-inflammatory effects, in part through their conversion to bioactive metabolites …
beneficial anti-inflammatory effects, in part through their conversion to bioactive metabolites …
Regulation of inflammation by cannabinoids, the endocannabinoids 2-arachidonoyl-glycerol and arachidonoyl-ethanolamide, and their metabolites
C Turcotte, F Chouinard, JS Lefebvre… - Journal of Leucocyte …, 2015 - academic.oup.com
Arachidonoyl-glycerol (2-AG) and arachidonyl-ethanolamide (AEA) are endocannabinoids
that have been implicated in many physiologic disorders, including obesity, metabolic …
that have been implicated in many physiologic disorders, including obesity, metabolic …
Endocannabinoid oxygenation by cyclooxygenases, lipoxygenases, and cytochromes P450: cross-talk between the eicosanoid and endocannabinoid signaling …
CA Rouzer, LJ Marnett - Chemical reviews, 2011 - ACS Publications
The discovery of the cannabinoid receptors CB1 and CB2 in 19881, 2 and 1990, 3
respectively, and of the endogenous cannabinoid ligands (endocannabinoids) …
respectively, and of the endogenous cannabinoid ligands (endocannabinoids) …
COX-2-derived endocannabinoid metabolites as novel inflammatory mediators
M Alhouayek, GG Muccioli - Trends in pharmacological sciences, 2014 - cell.com
Cyclooxygenase-2 (COX-2) is an enzyme that plays a key role in inflammatory processes.
Classically, this enzyme is upregulated in inflammatory situations and is responsible for the …
Classically, this enzyme is upregulated in inflammatory situations and is responsible for the …
Endocannabinoids, related compounds and their metabolic routes
Endocannabinoids are lipid mediators able to bind to and activate cannabinoid receptors,
the primary molecular targets responsible for the pharmacological effects of the Δ9 …
the primary molecular targets responsible for the pharmacological effects of the Δ9 …
Intracellular molecular targets and signaling pathways involved in antioxidative and neuroprotective effects of cannabinoids in neurodegenerative conditions
In the last few decades, endocannabinoids, plant-derived cannabinoids and synthetic
cannabinoids have received growing interest as treatment options in neurodegenerative …
cannabinoids have received growing interest as treatment options in neurodegenerative …
The role of n-3 PUFA-derived fatty acid derivatives and their oxygenated metabolites in the modulation of inflammation
Notwithstanding the ongoing debate on their full potential in health and disease, there is
general consensus that n-3 PUFAs play important physiological roles. Increasing dietary n-3 …
general consensus that n-3 PUFAs play important physiological roles. Increasing dietary n-3 …
Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer
G Zhang, S Kodani, BD Hammock - Progress in lipid research, 2014 - Elsevier
Epoxygenated fatty acids (EpFAs), which are lipid mediators produced by cytochrome P450
epoxygenases from polyunsaturated fatty acids, are important signaling molecules known to …
epoxygenases from polyunsaturated fatty acids, are important signaling molecules known to …