Development of biomimetic phospholipid membrane chromatography for drug discovery: A comprehensive review

J Wang, J Guo, D Xu, L He, JH Qu, Q Wang… - TrAC Trends in …, 2024 - Elsevier
Drug-membrane interactions are important physicochemical properties to be considered at
early drug discovery stage, which can provide deeper understanding of drug …

Liposomes: preparation and characterization with a special focus on the application of capillary electrophoresis

A Tomnikova, A Orgonikova, T Krizek - Monatshefte für Chemie-Chemical …, 2022 - Springer
Liposomes are nowadays a matter of tremendous interest. Due to their amphiphilic
character, various substances with different properties can be incorporated into them and …

Effect of liposome composition on β‐blocker interactions studied by capillary electrokinetic chromatography

H Ravald, AH Moghaddam, S Jaikishan… - Journal of …, 2023 - Wiley Online Library
Liposome capillary electrokinetic chromatography was used to investigate the interactions
between three β‐blockers of different hydrophobicity and various liposome solutions. The …

A study on attempt for determination of permeation kinetics of coumarin at lipid bilayer of liposomes by using capillary electrophoresis with moment analysis theory

K Miyabe, S Inaba, M Umeda - Journal of Chromatography A, 2023 - Elsevier
It was tried to develop a moment analysis method for the determination of lipid membrane
permeability. The first absolute and second central moments of elution peaks measured by …

[HTML][HTML] Recent trends in capillary electrokinetic chromatography with liposomes, lipid aggregates, and lipid emulsions

V Lishchuk, SK Wiedmer - Journal of Chromatography Open, 2024 - Elsevier
The main trends in the use of liposomes or lipid aggregates as pseudostationary phases in
capillary electrokinetic chromatography (EKC) over the past 15 years are reviewed. Due to …

OEA loaded liposomes with the neuroprotective effect for stroke therapy

S Wu, X Yang - Frontiers in Chemistry, 2022 - frontiersin.org
With high mortality, stroke has become a serious threat to human health. Nevertheless, the
strategy for stroke therapy is quite limited in the clinic till now. In this research, we prepared a …

Analysis of Mass Transfer Kinetics at Lipid Bilayer Membranes of Liposome by Means of Electrokinetic Chromatography and Moment Theory

K Miyabe, M Umeda, S Inaba… - Industrial & Engineering …, 2024 - ACS Publications
A method was developed for the kinetic study of mass transfer phenomena in liposome
electrokinetic chromatography (LEKC). It was tried to analyze structural characteristics of …

[HTML][HTML] Potential of liposomes and lipid membranes for the separation of β-blockers by capillary electromigration and liquid chromatographic techniques

H Ravald, SK Wiedmer - Journal of Chromatography A, 2023 - Elsevier
Abstract β-Blockers belong to a frequently used class of drugs primarily used to treat heart
and circulatory conditions. Here we describe the use of lipid vesicles and liposomes as cell …

Quantitative analysis of the membrane affinity of local anesthetics using a model cell membrane

W Choi, H Ryu, A Fuwad, S Goh, C Zhou, J Shim… - Membranes, 2021 - mdpi.com
Local anesthesia is a drug that penetrates the nerve cell membrane and binds to the voltage
gate sodium channel, inhibiting the membrane potential and neurotransmission. It is mainly …

Moment theory for the analytical determination of rate constants for solute permeation at the interface of spherical molecular aggregates

K Miyabe, S Senoo, N Okayasu - Electrophoresis, 2019 - Wiley Online Library
Moment equations were developed on the basis of the Einstein equation for diffusion and
the random walk model to analytically determine the rate constant for the interfacial solute …