Classical microtubule‐associated proteins (MAPs) were originally identified based on their
co‐purification with microtubules assembled from mammalian brain lysate. They have since …

Neurons are the basic information-processing units of the nervous system. In fulfilling their
task, they establish a structural polarity with an axon that can be over a meter long and …

TMEM 106B is a major risk factor for frontotemporal lobar degeneration with TDP‐43
pathology. TMEM 106B localizes to lysosomes, but its function remains unclear. We show …

Microtubule-associated proteins (MAPs) are main candidates to stabilize neuronal
microtubules, playing an important role in establishing axon-dendrite polarity. However, how …

Following a spinal cord injury (SCI) a growth aversive environment forms, consisting of a
fibroglial scar and inhibitory factors, further restricting the already low intrinsic growth …

Autophagy plays a key role in the pathophysiology of schizophrenia as manifested by a 40%
decrease in BECN1/Beclin 1 mRNA in postmortem hippocampal tissues relative to controls …

The development and function of the central nervous system rely on the microtubule (MT)
and actin cytoskeletons and their respective effectors. Although the structural role of the …

Drugs acting through 5-hydroxytryptamine (serotonin or 5-HT) systems modulate memory
and its alterations, although the mechanisms involved are poorly understood. 5-HT drugs …

Background Severe and medication-resistant psychiatric diseases, such as major
depressive disorder, bipolar disorder or schizophrenia, can be effectively and rapidly treated …

One major pathological process in Alzheimer's disease is mediated by hyperphosphorylated
tau, which includes altered microtubules (MTs) and functions associated with tau. A potential …