Kindred cells can have different genomes because of dynamic changes in DNA. Single-cell
sequencing is needed to characterize these genomic differences but has been hindered by …

P53 is a master transcriptional regulator controlling several main cellular pathways. Its role
is to adapt gene expression programs in order to maintain cellular homeostasis and genome …

Although it has been established that cannabidiol (CBD), the major non-psychoactive
constituent of cannabis, exerts antitumoral activities, the exact mechanism (s) via which …

Estrogen receptor β (ERβ) is the predominant ER in the colorectal epithelium. Compared
with normal colon tissue, ERβ expression is reduced in colorectal cancer. Our hypothesis is …

Aberrant activation of Wnt/β-catenin signaling is closely associated with the development of
various human cancers, especially colorectal cancers (CRC). The ubiquitin proteasome …

In recent years, accumulating evidence indicates that long noncoding RNAs (lncRNAs) have
emerged as powerful influence factors in the progression of multiple malignancies …

The TP53 gene is mutated in approximately 60% of all colorectal cancer (CRC) cases. Over
20% of all TP53-mutated CRC tumors carry missense mutations at position R175 or R273 …

Abstract Hypoxia‐inducible factor (HIF)‐1 and HIF‐2 are heterodimeric transcription factors
that mediate the cellular response to hypoxia. Their key regulatory subunits, HIF‐1α and HIF …

Oxaliplatin resistance is a major challenge in the clinical treatment for advanced colorectal
cancer (CRC). Long non-coding RNAs (lncRNAs) are involved in tumorigenesis and …

Several studies suggest estrogen to be protective against the development of colon cancer.
Estrogen receptor β (ERβ) is the predominant estrogen receptor expressed in colorectal …