The complex tumor microenvironment (TME) plays a vital role in cancer development and
dramatically determines the efficacy of immunotherapy. Tertiary lymphoid structures (TLSs) …

Advances in understanding the physiologic functions of the tumor necrosis factor
superfamily (TNFSF) of ligands, receptors, and signaling networks are providing deeper …

Glioblastomas are aggressive brain tumors that are largely immunotherapy resistant. This is
associated with immunosuppression and a dysfunctional tumor vasculature, which hinder T …

Abstract Non-suppressible HIV-1 viremia (NSV) is defined as persistent low-level viremia on
antiretroviral therapy (ART) without evidence of ART non-adherence or significant drug …

Preclinical and clinical antiangiogenic approaches, with multiple side effects such as
resistance, have not been proved to be very successful in treating tumor blood vessels …

Malignant T lymphocyte proliferation in mycosis fungoides (MF) is largely restricted to the
skin, implying that malignant cells are dependent on their specific cutaneous tumor …

Autoimmune diseases constitute a heterogeneous group of disorders with one common
feature–the loss of immune tolerance towards autoantigens. Due to the complexity of the …

Background: N6-methyladenosine (m6A), 5-methylcytosine (m5C) and N1-methyladenosine
(m1A) are the main RNA methylation modifications involved in the progression of cancer …

Background CAFs regulate the signaling of GC cells by promoting their migration, invasion,
and proliferation and the function of immune cells as well as their location and migration in …

Tertiary lymphoid structures (TLSs) in tumor tissues facilitate immune cell trafficking and
cytotoxicity, which benefits survival and favorable responses in immune therapy. Here, we …