Since the advent of induced pluripotent stem cell (iPSC) technology a decade ago,
enormous progress has been made in stem cell biology and regenerative medicine. Human …

At present, the idea of genome modification has revolutionized the modern therapeutic
research era. Genome modification studies have traveled a long way from gene …

T cells in the immune system protect the human body from infection by pathogens and clear
mutant cells through specific recognition by T cell receptors (TCRs). Cancer immunotherapy …

The discovery of induced pluripotent stem cells (iPSCs) has made an invaluable contribution
to the field of regenerative medicine, paving way for identifying the true potential of human …

Genome editing reemerged in 2012 with the development of CRISPR/Cas9 technology,
which is a genetic manipulation tool derived from the defense system of certain bacteria …

Clustered regularly-interspaced short palindromic repeat (CRISPR) sequences cooperate
with CRISPR-associated (Cas) proteins to form the basis of CRISPR-Cas adaptive immune …

From the beginning, induced pluripotent stem cell (iPSC) technology was touted as a path to
improve our understanding of disease biology and enable drug discovery. Advances in …

Cytokines are secreted or otherwise released polypeptide factors that exert autocrine and/or
paracrine actions, with most cytokines acting in the immune and/or hematopoietic system …

Severe combined immunodeficiency (SCID) is a group of disorders caused by mutations in
genes involved in the process of lymphocyte maturation and function. CRISPR-Cas9 gene …

The generation of induced pluripotent stem cells (iPSCs) from differentiated mature cells is
one of the most promising technologies in the field of regenerative medicine. The ability to …