Histamine was first identified in the brain about 50 years ago, but only in the last few years
have researchers gained an understanding of how it regulates sleep/wake behavior. We …

Histamine plays pleiotropic roles as a neurotransmitter in the physiology of brain function,
this includes the maintenance of wakefulness, appetite regulation and memory retrieval …

We screened for novel circuits in the mouse brain that promote wakefulness. Chemogenetic
activation experiments and electroencephalogram recordings pointed to …

As the brain transitions from wakefulness to sleep, processing of external information
diminishes while restorative processes, such as glymphatic removal of waste products, are …

Identification of mechanisms which increase deep sleep could lead to novel treatments
which promote the restorative effects of sleep. Here, we show that knockdown of the α3 …

Current GABAergic sleep-promoting medications were developed pragmatically, without
making use of the immense diversity of GABA A receptors. Pharmacogenetic experiments …

The lateral habenula has been widely studied for its contribution in generating reward-
related behaviors [1, 2]. We have found that this nucleus plays an unexpected role in the …

Abstract Study Objectives: Nonrapid eye movement sleep boosts hippocampus-dependent,
long-term memory formation more so than wake. Studies have pointed to several …

Histaminergic (HA) neurons, found in the posterior hypothalamic tuberomammillary nucleus
(TMN), extend fibers throughout the brain and exert modulatory influence over numerous …

Patients with Parkinson's disease (PD) suffer from severe sleep disorders. Pathophysiology
of the basal ganglia (BG) underlies PD, and the dorsal striatum represents the major input …