The phrenic neuromuscular system

DD Fuller, S Rana, AJ Smuder, EA Dale - Handbook of clinical neurology, 2022 - Elsevier
The phrenic neuromuscular system consists of the phrenic motor nucleus in the mid-cervical
spinal cord, the phrenic nerve, and the diaphragm muscle. This motor system helps sustain …

Rapid and robust restoration of breathing long after spinal cord injury

PM Warren, SC Steiger, TE Dick… - Nature …, 2018 - nature.com
There exists an abundance of barriers that hinder functional recovery following spinal cord
injury, especially at chronic stages. Here, we examine the rescue of breathing up to 1.5 …

Ampakines increase diaphragm activation following mid-cervical contusion injury in rats

S Rana, PP Thakre, DD Fuller - Experimental Neurology, 2024 - Elsevier
Ampakines are positive allosteric modulators of AMPA receptors. We hypothesized that low-
dose ampakine treatment increases diaphragm electromyogram (EMG) activity after mid …

Hypercapnia impacts neural drive and timing of diaphragm neuromotor control

OU Khurram, MJ Kantor-Gerber… - Journal of …, 2024 - journals.physiology.org
The neuromotor control of the diaphragm muscle (DIAm) involves motor unit recruitment,
sustained activity (incrementing and decrementing), and motor unit derecruitment, phases …

Neuromotor control of spontaneous quiet breathing in awake rats evaluated by assessments of diaphragm EMG stationarity

OU Khurram, CB Mantilla… - Journal of …, 2023 - journals.physiology.org
The neuromotor control of the diaphragm muscle (DIAm) is dynamic. The activity of the DIAm
can be recorded via electromyography (EMG), which represents the temporal summation of …

Identification of eupneic breathing using machine learning

OU Khurram, CB Mantilla… - Journal of …, 2024 - journals.physiology.org
The diaphragm muscle (DIAm) is the primary inspiratory muscle in mammals. In awake
animals, considerable heterogeneity in the electromyographic (EMG) activity of the DIAm …

Physiological analyses of swallowing changes due to chronic obstructive pulmonary disease in anesthetized male rats

K Nagoya, T Tsujimura, M Yoshihara… - Frontiers in …, 2024 - frontiersin.org
Chronic obstructive pulmonary disease (COPD) was previously known as chronic bronchitis
and emphysema. It has various main symptoms, such as dyspnea, chronic cough, and …

Automated evaluation of respiratory signals to provide insight into respiratory drive

OU Khurram, HM Gransee, GC Sieck… - Respiratory physiology & …, 2022 - Elsevier
The diaphragm muscle (DIAm) is the primary inspiratory muscle in mammals and is highly
active throughout life displaying rhythmic activity. The repetitive activation of the DIAm (and …

Oxygen inhalation improves postoperative survival in ketamine-xylazine anaesthetised rats: An observational study

M Mechelinck, C Kupp, JC Krüger, MA Habigt… - PLoS …, 2019 - journals.plos.org
Objective A simple but reliable and safe anaesthetic procedure is required for surgical
interventions in small rodents. Combined ketamine and xylazine injections are often used in …

Cervical spinal cord hemisection impacts sigh and the respiratory reset in male rats

MJ Fogarty, WZ Zhan, CB Mantilla… - Physiological …, 2024 - Wiley Online Library
Cervical spinal cord injury impacts ventilatory and non‐ventilatory functions of the
diaphragm muscle (DIAm) and contributes to clinical morbidity and mortality in the afflicted …